DegronMD

Uniprot ID: Q8NFU3

Source protein: Thiosulfate:glutathione sulfurtransferase

Source gene: TSTD1

Class: DEG_APCC_DBOX_1

Location: 19:27

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5381

ASA_SCORE: 34.6556

COIL: 0.5069

CONS_SCORE: 0.7499

DSS_SCORE: 0.2645

HELIX: 0.004

FCONS_SCORE: 1.0232

RIG_SCORE: 0.786

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R27S	DO229018	LICA	ICGC	GRARLFDVR	DEG_APCC_DBOX_1	0.6316
p.D25E	DO229027	LICA	ICGC	GRARLFDVR	DEG_APCC_DBOX_1	0.5647
p.T36N	DO229045	LICA	ICGC	GRARLFDVR	DEG_APCC_DBOX_1	0.0833
p.R13C	DO222753	MELA	ICGC	GRARLFDVR	DEG_APCC_DBOX_1	0.1667
p.A17V	SIDM01178	Other Solid Cancers	GDSC	GRARLFDVR	DEG_APCC_DBOX_1	0.2778
p.A17V	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	GRARLFDVR	DEG_APCC_DBOX_1	0.2778
p.F36L	OMC-1	cervix	COSMIC	GRARLFDVR	DEG_APCC_DBOX_1	0.0833
p.C26S	SK-N-AS	autonomic_ganglia	COSMIC	GRARLFDVR	DEG_APCC_DBOX_1	0.7541
p.F24L	OMC-1	cervix	COSMIC	GRARLFDVR	DEG_APCC_DBOX_1	0.587
p.L22F	OMC-1	cervix	COSMIC	GRARLFDVR	DEG_APCC_DBOX_1	0.6981
p.E32K	FADU	upper_aerodigestive_tract	COSMIC	GRARLFDVR	DEG_APCC_DBOX_1	0.1944
p.E20K	FADU	upper_aerodigestive_tract	COSMIC	GRARLFDVR	DEG_APCC_DBOX_1	0.7022
p.L34F	OMC-1	cervix	COSMIC	GRARLFDVR	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFU3	Thiosulfate:glutathione sulfurtransferase	DEG_APCC_DBOX_1	19:27	GRARLFDVR	APC,CDC20,FZR1	0.5381	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons