FBH1
UniProt ID: Q8NFZ0
Entrez ID: 84893
Protein name: F-box DNA helicase 1 (hFBH1) (EC 3.6.4.12) (F-box only protein 18)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and pre...
FUNCTION: 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578). {ECO:0000269|PubMed:11956208, ECO:0000269|PubMed:17724085, ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23319600, ECO:0000269|PubMed:23361013, ECO:0000269|PubMed:25585578, ECO:0000269|PubMed:25772361}.
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GO - Biological processes (BP):
cell death [GO:0008219]; cellular response to DNA damage stimulus [GO:0006974]; DNA catabolic process, endonucleolytic [GO:0000737]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of chromatin binding [GO:0035562]; negative regulation of double-strand break...
cell death [GO:0008219]; cellular response to DNA damage stimulus [GO:0006974]; DNA catabolic process, endonucleolytic [GO:0000737]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of chromatin binding [GO:0035562]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; recombinational repair [GO:0000725]; replication fork processing [GO:0031297]; replication fork protection [GO:0048478]; response to intra-S DNA damage checkpoint signaling [GO:0072429]
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GO - Molecular function (MF):
3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697]...
3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697]
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GO - Cellular component (CC):
chromatin [GO:0000785]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]...
chromatin [GO:0000785]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]
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FBH1
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Kaplan plot for FBH1 in
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*NOTE: the Kaplan plots were collected from OncoLnc