DegronMD

Uniprot ID: Q8NFZ0

Source protein: F-box DNA helicase 1

Source gene: FBH1

Class: DEG_APCC_DBOX_1

Location: 895:903

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5875

ASA_SCORE: 78.3778

COIL: 0.8273

CONS_SCORE: 0.3167

DSS_SCORE: 0.1142

HELIX: 0.1328

FCONS_SCORE: 0.7432

RIG_SCORE: 0.7954

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A889T	SIDM00781	Colorectal Carcinoma	GDSC	ARHNLPQLP	DEG_APCC_DBOX_1	0.1667
p.A889T	SIDM00780	Colorectal Carcinoma	GDSC	ARHNLPQLP	DEG_APCC_DBOX_1	0.1667
p.A889T	SNU-C2B	large_intestine	COSMIC	ARHNLPQLP	DEG_APCC_DBOX_1	0.1667
p.R896Q	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	ARHNLPQLP	DEG_APCC_DBOX_1	0.7329
p.C907Y	SNU-1040	large_intestine	COSMIC	ARHNLPQLP	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFZ0	F-box DNA helicase 1	DEG_APCC_DBOX_1	895:903	ARHNLPQLP	APC,CDC20,FZR1	0.5875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons