DegronMD - Q8NHL6(LILRB1)

GO - Biological processes (BP): adaptive immune response [GO:0002250]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; dendritic cell differentiation [GO:0097028]; Fc receptor mediated inhibitory signaling pathway [GO:0002774]; immune response-inhibiting cell surface receptor signaling pathway [GO:0002767]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of CD8-positive, alpha-beta T cell activation [GO:2001186]; negative regulation of cell cycle [GO:0045786]; negative regulation of cytokine production involved in immune response [GO:0002719]; negative regulation of dendritic cell apoptotic process [GO:2000669]; negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of endocytosis [GO:0045806]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of mononuclear cell proliferation [GO:0032945]; negative regulation of natural killer cell mediated cytotoxicity [GO:0045953]; negative regulation of osteoclast development [GO:2001205]; negative regulation of serotonin secretion [GO:0014063]; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [GO:2001189]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transforming growth factor beta production [GO:0071635]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of apoptotic process [GO:0043065]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gamma-delta T cell activation involved in immune response [GO:2001193]; positive regulation of gene expression [GO:0010628]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of transcription by RNA polymerase II [GO:0045944]; receptor internalization [GO:0031623]; response to virus [GO:0009615]; signal transduction [GO:0007165]; T cell proliferation involved in immune response [GO:0002309] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P633Q	TCGA-99-7458	LUAD	TCGA	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.3056
p.P633Q	DO25416	LUAD	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.3056
p.T629A	TCGA-AA-A010	COAD	TCGA	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.1944
p.R626Q	TCGA-AG-A002	READ	TCGA	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.1111
p.R626Q	TCGA-EO-A22U	UCEC	TCGA	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.1111
p.R626Q	DO224801	COCA	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.1111
p.R626Q	DO43755	UCEC	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.1111
p.Y646C	TCGA-AX-A063	UCEC	TCGA	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.25
p.Y646C	DO42201	UCEC	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.25
p.A647T	TCGA-CM-6162	COAD	TCGA	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.2222
p.A647T	DO8479	COAD	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.2222
p.A647T	SIDM01039	Other Solid Cancers	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.2222
p.S639F	TCGA-CR-7371	HNSC	TCGA	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7982
p.S639F	DO15454	HNSC	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7982
p.H652Y	TCGA-EE-A2GL	SKCM	TCGA	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.0833
p.H652Y	DO37434	SKCM	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.0833
p.S639Y	TCGA-GN-A26A	SKCM	TCGA	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.712
p.S639Y	DO37861	SKCM	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.712
p.S644C	TCGA-LT-A5Z6	BLCA	TCGA	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation blocking phosphorylation signal	0.75
p.S644C	DO44029	BLCA	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation blocking phosphorylation signal	0.75
p.R625K	TCGA-W3-A825	SKCM	TCGA	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.0833
p.R625K	DO51272	SKCM	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.0833
p.E627K	DO228483	BRCA	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.1389
p.E627K	DO229003	COCA	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.1389
p.E627K	DO231140	LAML	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.1389
p.E627K	DO231049	LUSC	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.1389
p.P640S	DO220881	MELA	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.6752
p.G637E	DO222647	MELA	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7199
p.P632L	DO222753	MELA	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.2778
p.S644N	DO222908	MELA	ICGC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation blocking phosphorylation signal	0.75
p.V642E	SIDM00958	Chronic Myelogenous Leukemia	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.V642E	SIDM00434	Plasma Cell Myeloma	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.V642E	SIDM00582	Pancreatic Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.V642E	SIDM01117	Small Cell Lung Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.V642E	SIDM00352	Ovarian Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.V642E	SIDM00496	Thyroid Gland Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.V642E	SIDM00879	Breast Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.V642E	SIDM00875	Breast Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.V642E	SIDM00930	Osteosarcoma	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.V642E	SIDM00363	Acute Myeloid Leukemia	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.V642E	SIDM00641	Burkitt's Lymphoma	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.V642E	SIDM01609	Endometrial Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.V642E	SIDM01472	Hepatocellular Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.V642E	SIDM00171	Colorectal Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.V642E	SIDM00016	Neuroblastoma	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7693
p.S644I	SIDM01343	Gastric Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation blocking phosphorylation signal	0.75
p.S642I	ACH-000764	Gastric Cancer	CCLE	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.7341
p.S630F	IGR-1	skin	COSMIC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.2222
p.S633Y	EPLC-272H	lung	COSMIC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.3056
p.E653K	BT-483	breast	COSMIC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation rewiring degron network	0.0556
p.Q643K	COLO-792	skin	COSMIC	EGPSPAVPSI	DEG_COP1_1	634:643	Mutation altering degron motif	0.6944

Kaplan plot for LILRB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LILRB1

UniProt ID: Q8NHL6

Entrez ID: 10859

Protein name: Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LILRB1 in