DegronMD

Uniprot ID: Q8NHL6

Source protein: Leukocyte immunoglobulin-like receptor subfamily B member 1

Source gene: LILRB1

Class: DEG_COP1_1

Location: 634:643

E3 ligase: COP1

DEGRON score: 0.9964

ASA_SCORE: 64.35

COIL: 0.8

CONS_SCORE: 0.5096

DSS_SCORE: 0.6739

HELIX: 0.08

FCONS_SCORE: 1.0466

RIG_SCORE: 0.6306

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P633Q	TCGA-99-7458	LUAD	TCGA	EGPSPAVPSI	DEG_COP1_1	0.3056
p.P633Q	DO25416	LUAD	ICGC	EGPSPAVPSI	DEG_COP1_1	0.3056
p.T629A	TCGA-AA-A010	COAD	TCGA	EGPSPAVPSI	DEG_COP1_1	0.1944
p.R626Q	TCGA-AG-A002	READ	TCGA	EGPSPAVPSI	DEG_COP1_1	0.1111
p.R626Q	TCGA-EO-A22U	UCEC	TCGA	EGPSPAVPSI	DEG_COP1_1	0.1111
p.R626Q	DO224801	COCA	ICGC	EGPSPAVPSI	DEG_COP1_1	0.1111
p.R626Q	DO43755	UCEC	ICGC	EGPSPAVPSI	DEG_COP1_1	0.1111
p.Y646C	TCGA-AX-A063	UCEC	TCGA	EGPSPAVPSI	DEG_COP1_1	0.25
p.Y646C	DO42201	UCEC	ICGC	EGPSPAVPSI	DEG_COP1_1	0.25
p.A647T	TCGA-CM-6162	COAD	TCGA	EGPSPAVPSI	DEG_COP1_1	0.2222
p.A647T	DO8479	COAD	ICGC	EGPSPAVPSI	DEG_COP1_1	0.2222
p.A647T	SIDM01039	Other Solid Cancers	GDSC	EGPSPAVPSI	DEG_COP1_1	0.2222
p.S639F	TCGA-CR-7371	HNSC	TCGA	EGPSPAVPSI	DEG_COP1_1	0.7982
p.S639F	DO15454	HNSC	ICGC	EGPSPAVPSI	DEG_COP1_1	0.7982
p.H652Y	TCGA-EE-A2GL	SKCM	TCGA	EGPSPAVPSI	DEG_COP1_1	0.0833
p.H652Y	DO37434	SKCM	ICGC	EGPSPAVPSI	DEG_COP1_1	0.0833
p.S639Y	TCGA-GN-A26A	SKCM	TCGA	EGPSPAVPSI	DEG_COP1_1	0.712
p.S639Y	DO37861	SKCM	ICGC	EGPSPAVPSI	DEG_COP1_1	0.712
p.S644C	TCGA-LT-A5Z6	BLCA	TCGA	EGPSPAVPSI	DEG_COP1_1	0.75
p.S644C	DO44029	BLCA	ICGC	EGPSPAVPSI	DEG_COP1_1	0.75
p.R625K	TCGA-W3-A825	SKCM	TCGA	EGPSPAVPSI	DEG_COP1_1	0.0833
p.R625K	DO51272	SKCM	ICGC	EGPSPAVPSI	DEG_COP1_1	0.0833
p.E627K	DO228483	BRCA	ICGC	EGPSPAVPSI	DEG_COP1_1	0.1389
p.E627K	DO229003	COCA	ICGC	EGPSPAVPSI	DEG_COP1_1	0.1389
p.E627K	DO231140	LAML	ICGC	EGPSPAVPSI	DEG_COP1_1	0.1389
p.E627K	DO231049	LUSC	ICGC	EGPSPAVPSI	DEG_COP1_1	0.1389
p.P640S	DO220881	MELA	ICGC	EGPSPAVPSI	DEG_COP1_1	0.6752
p.G637E	DO222647	MELA	ICGC	EGPSPAVPSI	DEG_COP1_1	0.7199
p.P632L	DO222753	MELA	ICGC	EGPSPAVPSI	DEG_COP1_1	0.2778
p.S644N	DO222908	MELA	ICGC	EGPSPAVPSI	DEG_COP1_1	0.75
p.V642E	SIDM00958	Chronic Myelogenous Leukemia	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.V642E	SIDM00434	Plasma Cell Myeloma	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.V642E	SIDM00582	Pancreatic Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.V642E	SIDM01117	Small Cell Lung Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.V642E	SIDM00352	Ovarian Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.V642E	SIDM00496	Thyroid Gland Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.V642E	SIDM00879	Breast Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.V642E	SIDM00875	Breast Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.V642E	SIDM00930	Osteosarcoma	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.V642E	SIDM00363	Acute Myeloid Leukemia	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.V642E	SIDM00641	Burkitt's Lymphoma	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.V642E	SIDM01609	Endometrial Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.V642E	SIDM01472	Hepatocellular Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.V642E	SIDM00171	Colorectal Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.V642E	SIDM00016	Neuroblastoma	GDSC	EGPSPAVPSI	DEG_COP1_1	0.7693
p.S644I	SIDM01343	Gastric Carcinoma	GDSC	EGPSPAVPSI	DEG_COP1_1	0.75
p.S642I	ACH-000764	Gastric Cancer	CCLE	EGPSPAVPSI	DEG_COP1_1	0.7341
p.S630F	IGR-1	skin	COSMIC	EGPSPAVPSI	DEG_COP1_1	0.2222
p.S633Y	EPLC-272H	lung	COSMIC	EGPSPAVPSI	DEG_COP1_1	0.3056
p.E653K	BT-483	breast	COSMIC	EGPSPAVPSI	DEG_COP1_1	0.0556
p.Q643K	COLO-792	skin	COSMIC	EGPSPAVPSI	DEG_COP1_1	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EGPSPAVPSI

Degron related mutations and impact score

Drug responses associated with LILRB1 mutations

All proteins holding degron of EGPSPAVPSI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NHL6	Leukocyte immunoglobulin-like receptor subfamily B member 1	DEG_COP1_1	634:643	EGPSPAVPSI	COP1	0.9964	More...