DegronMD - Q8NHP6(MOSPD2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S240R	TCGA-IB-7651	PAAD	TCGA	DPFKYSYPP	CBL_PTK	235:243	Mutation altering degron motif	0.7427
p.S240R	DO46657	PAAD	ICGC	DPFKYSYPP	CBL_PTK	235:243	Mutation altering degron motif	0.7427
p.E225G	TCGA-TN-A7HJ	HNSC	TCGA	DPFKYSYPP	CBL_PTK	235:243	Mutation rewiring degron network	0.0556
p.E225G	DO219077	HNSC	ICGC	DPFKYSYPP	CBL_PTK	235:243	Mutation rewiring degron network	0.0556
p.T251A	TCGA-UY-A8OC	BLCA	TCGA	DPFKYSYPP	CBL_PTK	235:243	Mutation rewiring degron network	0.1111
p.T251A	DO219038	BLCA	ICGC	DPFKYSYPP	CBL_PTK	235:243	Mutation rewiring degron network	0.1111
p.K238N	DO228971	LICA	ICGC	DPFKYSYPP	CBL_PTK	235:243	Mutation altering degron motif	0.5806
p.M231I	DO229009	LICA	ICGC	DPFKYSYPP	CBL_PTK	235:243	Mutation rewiring degron network	0.2222
p.H230Q	DO232061	ORCA	ICGC	DPFKYSYPP	CBL_PTK	235:243	Mutation rewiring degron network	0.1944
p.T251I	ACH-001196	Sarcoma	CCLE	DPFKYSYPP	CBL_PTK	235:243	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons