DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DPFKYSYPP
Uniprot ID:
Q8NHP6
Source protein:
Motile sperm domain-containing protein 2
Source gene:
MOSPD2
Class:
CBL_PTK
Location:
235:243
E3 ligase:
CBL
DEGRON score:
0.9941
ASA_SCORE:
71.9333
COIL:
0.893
CONS_SCORE:
0.4345
DSS_SCORE:
0.4945
HELIX:
0.0271
FCONS_SCORE:
0.9353
RIG_SCORE:
0.7422
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S240R
TCGA-IB-7651
PAAD
TCGA
DPFKYSYPP
CBL_PTK
0.7427
p.S240R
DO46657
PAAD
ICGC
DPFKYSYPP
CBL_PTK
0.7427
p.E225G
TCGA-TN-A7HJ
HNSC
TCGA
DPFKYSYPP
CBL_PTK
0.0556
p.E225G
DO219077
HNSC
ICGC
DPFKYSYPP
CBL_PTK
0.0556
p.T251A
TCGA-UY-A8OC
BLCA
TCGA
DPFKYSYPP
CBL_PTK
0.1111
p.T251A
DO219038
BLCA
ICGC
DPFKYSYPP
CBL_PTK
0.1111
p.K238N
DO228971
LICA
ICGC
DPFKYSYPP
CBL_PTK
0.5806
p.M231I
DO229009
LICA
ICGC
DPFKYSYPP
CBL_PTK
0.2222
p.H230Q
DO232061
ORCA
ICGC
DPFKYSYPP
CBL_PTK
0.1944
p.T251I
ACH-001196
Sarcoma
CCLE
DPFKYSYPP
CBL_PTK
0.1111
Drug responses associated with MOSPD2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DPFKYSYPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NHP6
Motile sperm domain-containing protein 2
CBL_PTK
235:243
DPFKYSYPP
CBL
0.9941
More...
