DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DPFKYSYPP
Uniprot ID:
Q8NHP6
Source protein:
Motile sperm domain-containing protein 2
Source gene:
MOSPD2
Class:
CBL_PTK
Location:
235:243
E3 ligase:
CBL
DEGRON score:
0.9941
ASA_SCORE:
71.9333
COIL:
0.893
CONS_SCORE:
0.4345
DSS_SCORE:
0.4945
HELIX:
0.0271
FCONS_SCORE:
0.9353
RIG_SCORE:
0.7422
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S240R
TCGA-IB-7651
PAAD
TCGA
DPFKYSYPP
CBL_PTK
0.7427
p.S240R
DO46657
PAAD
ICGC
DPFKYSYPP
CBL_PTK
0.7427
p.K238N
DO228971
LICA
ICGC
DPFKYSYPP
CBL_PTK
0.5806
p.M231I
DO229009
LICA
ICGC
DPFKYSYPP
CBL_PTK
0.2222
p.H230Q
DO232061
ORCA
ICGC
DPFKYSYPP
CBL_PTK
0.1944
p.T251A
TCGA-UY-A8OC
BLCA
TCGA
DPFKYSYPP
CBL_PTK
0.1111
p.T251A
DO219038
BLCA
ICGC
DPFKYSYPP
CBL_PTK
0.1111
p.T251I
ACH-001196
Sarcoma
CCLE
DPFKYSYPP
CBL_PTK
0.1111
p.E225G
TCGA-TN-A7HJ
HNSC
TCGA
DPFKYSYPP
CBL_PTK
0.0556
p.E225G
DO219077
HNSC
ICGC
DPFKYSYPP
CBL_PTK
0.0556
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Drug responses associated with MOSPD2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of DPFKYSYPP
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NHP6
Motile sperm domain-containing protein 2
CBL_PTK
235:243
DPFKYSYPP
CBL
0.9941
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