DegronMD - Q8NHP7(EXD1)

EXD1

Please click HERE for better display.

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H435R	TCGA-AX-A06L	UCEC	TCGA	MTPKHE	DEG_SCF_FBW7_2	431:436	Mutation altering degron motif	0.7133
p.H435R	DO43851	UCEC	ICGC	MTPKHE	DEG_SCF_FBW7_2	431:436	Mutation altering degron motif	0.7133
p.E445K	DO222725	ESCA	ICGC	MTPKHE	DEG_SCF_FBW7_2	431:436	Mutation rewiring degron network	0.0833
p.Q422K	DO228976	LICA	ICGC	MTPKHE	DEG_SCF_FBW7_2	431:436	Mutation rewiring degron network	0.0833
p.H429Q	DO229006	LICA	ICGC	MTPKHE	DEG_SCF_FBW7_2	431:436	Mutation rewiring degron network	0.2778
p.G433E	SIDM00515	Melanoma	GDSC	MTPKHE	DEG_SCF_FBW7_2	431:436	Mutation altering degron motif	0.7199
p.G433E	ACH-000401	Skin Cancer	CCLE	MTPKHE	DEG_SCF_FBW7_2	431:436	Mutation altering degron motif	0.7199
p.G433E	ACH-001339	Skin Cancer	CCLE	MTPKHE	DEG_SCF_FBW7_2	431:436	Mutation altering degron motif	0.7199
p.G433E	COLO-800	skin	COSMIC	MTPKHE	DEG_SCF_FBW7_2	431:436	Mutation altering degron motif	0.7199
p.N436S	SIDM01588	Endometrial Carcinoma	GDSC	MTPKHE	DEG_SCF_FBW7_2	431:436	Mutation altering degron motif	0.7069
p.N436S	ACH-000993	Endometrial/Uterine Cancer	CCLE	MTPKHE	DEG_SCF_FBW7_2	431:436	Mutation altering degron motif	0.7069
p.D430Y	SIDM01588	Endometrial Carcinoma	GDSC	MTPKHE	DEG_SCF_FBW7_2	431:436	Mutation rewiring degron network	0.3056
p.D430Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	MTPKHE	DEG_SCF_FBW7_2	431:436	Mutation rewiring degron network	0.3056

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc