DegronMD

Uniprot ID: Q8NHP7

Source protein: piRNA biogenesis protein EXD1

Source gene: EXD1

Class: DEG_SCF_FBW7_2

Location: 431:436

E3 ligase: FBXW7

DEGRON score: 0.5563

ASA_SCORE: 104.2

COIL: 0.774

CONS_SCORE: 0.3044

DSS_SCORE: 0.5131

HELIX: 0.1612

FCONS_SCORE: 0.9564

RIG_SCORE: 0.7252

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H435R	TCGA-AX-A06L	UCEC	TCGA	MTPKHE	DEG_SCF_FBW7_2	0.7133
p.H435R	DO43851	UCEC	ICGC	MTPKHE	DEG_SCF_FBW7_2	0.7133
p.E445K	DO222725	ESCA	ICGC	MTPKHE	DEG_SCF_FBW7_2	0.0833
p.Q422K	DO228976	LICA	ICGC	MTPKHE	DEG_SCF_FBW7_2	0.0833
p.H429Q	DO229006	LICA	ICGC	MTPKHE	DEG_SCF_FBW7_2	0.2778
p.G433E	SIDM00515	Melanoma	GDSC	MTPKHE	DEG_SCF_FBW7_2	0.7199
p.G433E	ACH-000401	Skin Cancer	CCLE	MTPKHE	DEG_SCF_FBW7_2	0.7199
p.G433E	ACH-001339	Skin Cancer	CCLE	MTPKHE	DEG_SCF_FBW7_2	0.7199
p.G433E	COLO-800	skin	COSMIC	MTPKHE	DEG_SCF_FBW7_2	0.7199
p.N436S	SIDM01588	Endometrial Carcinoma	GDSC	MTPKHE	DEG_SCF_FBW7_2	0.7069
p.N436S	ACH-000993	Endometrial/Uterine Cancer	CCLE	MTPKHE	DEG_SCF_FBW7_2	0.7069
p.D430Y	SIDM01588	Endometrial Carcinoma	GDSC	MTPKHE	DEG_SCF_FBW7_2	0.3056
p.D430Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	MTPKHE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NHP7	piRNA biogenesis protein EXD1	DEG_SCF_FBW7_2	431:436	MTPKHE	FBXW7	0.5563	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons