DegronMD - Q8NHQ8(RASSF8)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T100A	TCGA-2W-A8YY	CESC	TCGA	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2778
p.T100A	DO223732	CESC	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2778
p.T100I	TCGA-AP-A1DK	UCEC	TCGA	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2778
p.T100I	DO42033	UCEC	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2778
p.I116V	TCGA-B5-A3FA	UCEC	TCGA	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.1667
p.I116V	DO52402	UCEC	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.1667
p.P107S	TCGA-BR-4361	STAD	TCGA	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.5641
p.P107S	DO38887	STAD	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.5641
p.P107S	SIDM01278	Colorectal Carcinoma	GDSC	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.5641
p.P114T	TCGA-BT-A0S7	BLCA	TCGA	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2222
p.P114T	DO504	BLCA	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2222
p.L101S	TCGA-EE-A3JD	SKCM	TCGA	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.3056
p.L101S	DO50299	SKCM	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.3056
p.L106M	TCGA-VQ-A8P2	STAD	TCGA	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.711
p.L106M	DO51761	STAD	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.711
p.L112R	DO8264	COAD	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2778
p.V93L	DO228952	LICA	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0833
p.P107R	SIDM02053	Colorectal Carcinoma	GDSC	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.6401
p.R99I	SIDM00420	Bladder Carcinoma	GDSC	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.25
p.R99I	ACH-000566	Bladder Cancer	CCLE	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.25
p.R99I	SW1710	urinary tract	COSMIC	YRQSLPPLA	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RASSF8

UniProt ID: Q8NHQ8

Entrez ID: 11228

Protein name: Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RASSF8 in