DegronMD

Uniprot ID: Q8NHQ8

Source protein: Ras association domain-containing protein 8

Source gene: RASSF8

Class: DEG_APCC_DBOX_1

Location: 102:110

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9987

ASA_SCORE: 83.2778

COIL: 0.7012

CONS_SCORE: 0.5671

DSS_SCORE: 0.5165

HELIX: 0.2711

FCONS_SCORE: 1.187

RIG_SCORE: 0.7353

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T100A	TCGA-2W-A8YY	CESC	TCGA	YRQSLPPLA	DEG_APCC_DBOX_1	0.2778
p.T100A	DO223732	CESC	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	0.2778
p.T100I	TCGA-AP-A1DK	UCEC	TCGA	YRQSLPPLA	DEG_APCC_DBOX_1	0.2778
p.T100I	DO42033	UCEC	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	0.2778
p.I116V	TCGA-B5-A3FA	UCEC	TCGA	YRQSLPPLA	DEG_APCC_DBOX_1	0.1667
p.I116V	DO52402	UCEC	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	0.1667
p.P107S	TCGA-BR-4361	STAD	TCGA	YRQSLPPLA	DEG_APCC_DBOX_1	0.5641
p.P107S	DO38887	STAD	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	0.5641
p.P107S	SIDM01278	Colorectal Carcinoma	GDSC	YRQSLPPLA	DEG_APCC_DBOX_1	0.5641
p.P114T	TCGA-BT-A0S7	BLCA	TCGA	YRQSLPPLA	DEG_APCC_DBOX_1	0.2222
p.P114T	DO504	BLCA	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	0.2222
p.L101S	TCGA-EE-A3JD	SKCM	TCGA	YRQSLPPLA	DEG_APCC_DBOX_1	0.3056
p.L101S	DO50299	SKCM	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	0.3056
p.L106M	TCGA-VQ-A8P2	STAD	TCGA	YRQSLPPLA	DEG_APCC_DBOX_1	0.711
p.L106M	DO51761	STAD	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	0.711
p.L112R	DO8264	COAD	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	0.2778
p.V93L	DO228952	LICA	ICGC	YRQSLPPLA	DEG_APCC_DBOX_1	0.0833
p.P107R	SIDM02053	Colorectal Carcinoma	GDSC	YRQSLPPLA	DEG_APCC_DBOX_1	0.6401
p.R99I	SIDM00420	Bladder Carcinoma	GDSC	YRQSLPPLA	DEG_APCC_DBOX_1	0.25
p.R99I	ACH-000566	Bladder Cancer	CCLE	YRQSLPPLA	DEG_APCC_DBOX_1	0.25
p.R99I	SW1710	urinary_tract	COSMIC	YRQSLPPLA	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NHQ8	Ras association domain-containing protein 8	DEG_APCC_DBOX_1	102:110	YRQSLPPLA	APC,CDC20,FZR1	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons