DegronMD - Q8NHS0(DNAJB8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M188I	TCGA-AA-3819	COAD	TCGA	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.2778
p.M188I	DO10590	COAD	ICGC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.2778
p.G191D	TCGA-AZ-4615	COAD	TCGA	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.1944
p.G191D	DO7977	COAD	ICGC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.1944
p.I189S	TCGA-CC-A8HV	LIHC	TCGA	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.25
p.I189S	DO52189	LIHC	ICGC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.25
p.F179C	TCGA-DD-A3A9	LIHC	TCGA	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.25
p.F179C	DO44888	LIHC	ICGC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.25
p.S184L	TCGA-FW-A3R5	SKCM	TCGA	VMSST	DEG_SPOP_SBC_1	182:186	Mutation altering degron motif	0.7667
p.S184L	DO37406	SKCM	ICGC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation altering degron motif	0.7667
p.S184L	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation altering degron motif	0.7667
p.S184L	PC-3_[JPC-3]	lung	COSMIC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation altering degron motif	0.7667
p.N190S	TCGA-GL-A9DE	KIRP	TCGA	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.2222
p.N190S	DO51560	KIRP	ICGC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.2222
p.E187D	TCGA-O2-A52N	LUSC	TCGA	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.3056
p.E187D	DO219217	LUSC	ICGC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.3056
p.S184A	TCGA-XU-AAXX	THYM	TCGA	VMSST	DEG_SPOP_SBC_1	182:186	Mutation altering degron motif	0.7588
p.T186P	DO227745	COCA	ICGC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation altering degron motif	0.7031
p.H192Q	DO228948	LICA	ICGC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.1667
p.S181L	SIDM01199	Hepatocellular Carcinoma	GDSC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.3056
p.S181L	SIDM00581	Glioblastoma	GDSC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.3056
p.S181L	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.3056
p.S181L	SIDM00045	Gastric Carcinoma	GDSC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.3056
p.S181L	SIDM01347	Ovarian Carcinoma	GDSC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.3056
p.S181L	SIDM01588	Endometrial Carcinoma	GDSC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.3056
p.S172P	SIDM01450	Gastric Carcinoma	GDSC	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.0556
p.S172P	ACH-000898	Gastric Cancer	CCLE	VMSST	DEG_SPOP_SBC_1	182:186	Mutation rewiring degron network	0.0556

Kaplan plot for DNAJB8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAJB8

UniProt ID: Q8NHS0

Entrez ID: 165721

Protein name: DnaJ homolog subfamily B member 8

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAJB8 in