DegronMD

Uniprot ID: Q8NHS0

Source protein: DnaJ homolog subfamily B member 8

Source gene: DNAJB8

Class: DEG_SPOP_SBC_1

Location: 182:186

E3 ligase: SPOP

DEGRON score: 0.9047

ASA_SCORE: 78.74

COIL: 0.5934

CONS_SCORE: 0.6489

DSS_SCORE: 0.4896

HELIX: 0.0098

FCONS_SCORE: 1.2039

RIG_SCORE: 0.6968

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S184L	TCGA-FW-A3R5	SKCM	TCGA	VMSST	DEG_SPOP_SBC_1	0.7667
p.S184L	DO37406	SKCM	ICGC	VMSST	DEG_SPOP_SBC_1	0.7667
p.S184L	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	VMSST	DEG_SPOP_SBC_1	0.7667
p.S184L	PC-3_[JPC-3]	lung	COSMIC	VMSST	DEG_SPOP_SBC_1	0.7667
p.S184A	TCGA-XU-AAXX	THYM	TCGA	VMSST	DEG_SPOP_SBC_1	0.7588
p.T186P	DO227745	COCA	ICGC	VMSST	DEG_SPOP_SBC_1	0.7031
p.E187D	TCGA-O2-A52N	LUSC	TCGA	VMSST	DEG_SPOP_SBC_1	0.3056
p.E187D	DO219217	LUSC	ICGC	VMSST	DEG_SPOP_SBC_1	0.3056
p.S181L	SIDM01199	Hepatocellular Carcinoma	GDSC	VMSST	DEG_SPOP_SBC_1	0.3056
p.S181L	SIDM00581	Glioblastoma	GDSC	VMSST	DEG_SPOP_SBC_1	0.3056
p.S181L	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VMSST	DEG_SPOP_SBC_1	0.3056
p.S181L	SIDM00045	Gastric Carcinoma	GDSC	VMSST	DEG_SPOP_SBC_1	0.3056
p.S181L	SIDM01347	Ovarian Carcinoma	GDSC	VMSST	DEG_SPOP_SBC_1	0.3056
p.S181L	SIDM01588	Endometrial Carcinoma	GDSC	VMSST	DEG_SPOP_SBC_1	0.3056
p.M188I	TCGA-AA-3819	COAD	TCGA	VMSST	DEG_SPOP_SBC_1	0.2778
p.M188I	DO10590	COAD	ICGC	VMSST	DEG_SPOP_SBC_1	0.2778
p.I189S	TCGA-CC-A8HV	LIHC	TCGA	VMSST	DEG_SPOP_SBC_1	0.25
p.I189S	DO52189	LIHC	ICGC	VMSST	DEG_SPOP_SBC_1	0.25
p.F179C	TCGA-DD-A3A9	LIHC	TCGA	VMSST	DEG_SPOP_SBC_1	0.25
p.F179C	DO44888	LIHC	ICGC	VMSST	DEG_SPOP_SBC_1	0.25
p.N190S	TCGA-GL-A9DE	KIRP	TCGA	VMSST	DEG_SPOP_SBC_1	0.2222
p.N190S	DO51560	KIRP	ICGC	VMSST	DEG_SPOP_SBC_1	0.2222
p.G191D	TCGA-AZ-4615	COAD	TCGA	VMSST	DEG_SPOP_SBC_1	0.1944
p.G191D	DO7977	COAD	ICGC	VMSST	DEG_SPOP_SBC_1	0.1944
p.H192Q	DO228948	LICA	ICGC	VMSST	DEG_SPOP_SBC_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NHS0	DnaJ homolog subfamily B member 8	DEG_SPOP_SBC_1	182:186	VMSST	SPOP	0.9047	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons