DegronMD - Q8NHX4(SPATA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T54R	TCGA-BC-A10U	LIHC	TCGA	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation altering degron motif	0.7876
p.T54R	DO22926	LIHC	ICGC	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation altering degron motif	0.7876
p.E52Q	DO48402	BLCA	ICGC	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation altering degron motif	0.5633
p.S53F	DO222884	COCA	ICGC	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation altering degron motif	0.6871
p.P51T	DO15870	HNSC	ICGC	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation altering degron motif	0.7031
p.S50I	DO229037	LICA	ICGC	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.3056
p.T54A	DO231040	LUSC	ICGC	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation altering degron motif	0.7139
p.Q48H	SIDM00232	Kidney Carcinoma	GDSC	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.25
p.Q48H	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.25
p.P49R	SIDM01098	Neuroblastoma	GDSC	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.2778
p.P49R	ACH-000149	Neuroblastoma	CCLE	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.2778
p.P49R	ACH-001188	Neuroblastoma	CCLE	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.2778
p.P49R	SK-N-SH	autonomic ganglia	COSMIC	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.2778
p.E61K	ACH-002396	Bone Cancer	CCLE	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.25
p.E61K	Sarc9371	bone	COSMIC	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.25
p.R68C	SNU-61	large intestine	COSMIC	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.0556
p.E50K	Sarc9371	bone	COSMIC	PESTPQHS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.3056

Kaplan plot for SPATA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA3

UniProt ID: Q8NHX4

Entrez ID: 130560

Protein name: Spermatogenesis-associated protein 3 (Testis and spermatogenesis cell-related protein 1) (Testis spermatocyte apoptosis-related protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATA3 in