DegronMD

Uniprot ID: Q8NHX4

Source protein: Spermatogenesis-associated protein 3

Source gene: SPATA3

Class: DEG_SCF_FBW7_1

Location: 51:58

E3 ligase: FBXW7

DEGRON score: 0.558

ASA_SCORE: 90.6875

COIL: 0.9216

CONS_SCORE: 0.5372

DSS_SCORE: 0.9072

HELIX: 0.0501

FCONS_SCORE: 0.861

RIG_SCORE: 0.4742

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T54R	TCGA-BC-A10U	LIHC	TCGA	PESTPQHS	DEG_SCF_FBW7_1	0.7876
p.T54R	DO22926	LIHC	ICGC	PESTPQHS	DEG_SCF_FBW7_1	0.7876
p.E52Q	DO48402	BLCA	ICGC	PESTPQHS	DEG_SCF_FBW7_1	0.5633
p.S53F	DO222884	COCA	ICGC	PESTPQHS	DEG_SCF_FBW7_1	0.6871
p.P51T	DO15870	HNSC	ICGC	PESTPQHS	DEG_SCF_FBW7_1	0.7031
p.S50I	DO229037	LICA	ICGC	PESTPQHS	DEG_SCF_FBW7_1	0.3056
p.T54A	DO231040	LUSC	ICGC	PESTPQHS	DEG_SCF_FBW7_1	0.7139
p.Q48H	SIDM00232	Kidney Carcinoma	GDSC	PESTPQHS	DEG_SCF_FBW7_1	0.25
p.Q48H	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PESTPQHS	DEG_SCF_FBW7_1	0.25
p.P49R	SIDM01098	Neuroblastoma	GDSC	PESTPQHS	DEG_SCF_FBW7_1	0.2778
p.P49R	ACH-000149	Neuroblastoma	CCLE	PESTPQHS	DEG_SCF_FBW7_1	0.2778
p.P49R	ACH-001188	Neuroblastoma	CCLE	PESTPQHS	DEG_SCF_FBW7_1	0.2778
p.P49R	SK-N-SH	autonomic_ganglia	COSMIC	PESTPQHS	DEG_SCF_FBW7_1	0.2778
p.E61K	ACH-002396	Bone Cancer	CCLE	PESTPQHS	DEG_SCF_FBW7_1	0.25
p.E61K	Sarc9371	bone	COSMIC	PESTPQHS	DEG_SCF_FBW7_1	0.25
p.R68C	SNU-61	large_intestine	COSMIC	PESTPQHS	DEG_SCF_FBW7_1	0.0556
p.E50K	Sarc9371	bone	COSMIC	PESTPQHS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NHX4	Spermatogenesis-associated protein 3	DEG_SCF_FBW7_1	51:58	PESTPQHS	FBXW7	0.558	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons