DegronMD - Q8TAC9(SCAMP5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A225T	TCGA-AY-A69D	COAD	TCGA	NQPQTQYSATP	CBL_PTK	217:227	Mutation altering degron motif	0.6028
p.A225T	TCGA-EO-A22R	UCEC	TCGA	NQPQTQYSATP	CBL_PTK	217:227	Mutation altering degron motif	0.6028
p.A212T	TCGA-BR-4184	STAD	TCGA	NQPQTQYSATP	CBL_PTK	217:227	Mutation rewiring degron network	0.1944
p.A212T	TCGA-EE-A29E	SKCM	TCGA	NQPQTQYSATP	CBL_PTK	217:227	Mutation rewiring degron network	0.1944
p.A220T	DO37831	SKCM	ICGC	NQPQTQYSATP	CBL_PTK	217:227	Mutation altering degron motif	0.7139
p.A220T	DO38328	STAD	ICGC	NQPQTQYSATP	CBL_PTK	217:227	Mutation altering degron motif	0.7139
p.A207T	SIDM00367	Small Cell Lung Carcinoma	GDSC	NQPQTQYSATP	CBL_PTK	217:227	Mutation rewiring degron network	0.0556
p.A207T	ACH-002197	Lung Cancer	CCLE	NQPQTQYSATP	CBL_PTK	217:227	Mutation rewiring degron network	0.0556
p.A207T	SBC-3	lung	COSMIC	NQPQTQYSATP	CBL_PTK	217:227	Mutation rewiring degron network	0.0556
p.A211V	SIDM00463	T-Lymphoblastic Leukemia	GDSC	NQPQTQYSATP	CBL_PTK	217:227	Mutation rewiring degron network	0.1667
p.A211V	ACH-000372	Leukemia	CCLE	NQPQTQYSATP	CBL_PTK	217:227	Mutation rewiring degron network	0.1667
p.A211V	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	NQPQTQYSATP	CBL_PTK	217:227	Mutation rewiring degron network	0.1667
p.Q222E	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	NQPQTQYSATP	CBL_PTK	217:227	Mutation altering degron motif	0.5633
p.Q222E	H513	pleura	COSMIC	NQPQTQYSATP	CBL_PTK	217:227	Mutation altering degron motif	0.5633
p.A215T	SBC-3	lung	COSMIC	NQPQTQYSATP	CBL_PTK	217:227	Mutation rewiring degron network	0.2778
p.A219V	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	NQPQTQYSATP	CBL_PTK	217:227	Mutation altering degron motif	0.6936
p.Q230E	H513	pleura	COSMIC	NQPQTQYSATP	CBL_PTK	217:227	Mutation blocking phosphorylation signal	0.6944

Kaplan plot for SCAMP5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCAMP5

UniProt ID: Q8TAC9

Entrez ID: 192683

Protein name: Secretory carrier-associated membrane protein 5 (Secretory carrier membrane protein 5) (hSCAMP5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCAMP5 in