DegronMD

Uniprot ID: Q8TAC9

Source protein: Secretory carrier-associated membrane protein 5

Source gene: SCAMP5

Class: CBL_PTK

Location: 217:227

E3 ligase: CBL

DEGRON score: 0.8493

ASA_SCORE: 80.5909

COIL: 0.8703

CONS_SCORE: 0.2521

DSS_SCORE: 0.523

HELIX: 0.0882

FCONS_SCORE: 0.912

RIG_SCORE: 0.6794

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A225T	TCGA-AY-A69D	COAD	TCGA	NQPQTQYSATP	CBL_PTK	0.6028
p.A225T	TCGA-EO-A22R	UCEC	TCGA	NQPQTQYSATP	CBL_PTK	0.6028
p.A212T	TCGA-BR-4184	STAD	TCGA	NQPQTQYSATP	CBL_PTK	0.1944
p.A212T	TCGA-EE-A29E	SKCM	TCGA	NQPQTQYSATP	CBL_PTK	0.1944
p.A220T	DO37831	SKCM	ICGC	NQPQTQYSATP	CBL_PTK	0.7139
p.A220T	DO38328	STAD	ICGC	NQPQTQYSATP	CBL_PTK	0.7139
p.A207T	SIDM00367	Small Cell Lung Carcinoma	GDSC	NQPQTQYSATP	CBL_PTK	0.0556
p.A207T	ACH-002197	Lung Cancer	CCLE	NQPQTQYSATP	CBL_PTK	0.0556
p.A207T	SBC-3	lung	COSMIC	NQPQTQYSATP	CBL_PTK	0.0556
p.A211V	SIDM00463	T-Lymphoblastic Leukemia	GDSC	NQPQTQYSATP	CBL_PTK	0.1667
p.A211V	ACH-000372	Leukemia	CCLE	NQPQTQYSATP	CBL_PTK	0.1667
p.A211V	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	NQPQTQYSATP	CBL_PTK	0.1667
p.Q222E	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	NQPQTQYSATP	CBL_PTK	0.5633
p.Q222E	H513	pleura	COSMIC	NQPQTQYSATP	CBL_PTK	0.5633
p.A215T	SBC-3	lung	COSMIC	NQPQTQYSATP	CBL_PTK	0.2778
p.A219V	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	NQPQTQYSATP	CBL_PTK	0.6936
p.Q230E	H513	pleura	COSMIC	NQPQTQYSATP	CBL_PTK	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TAC9	Secretory carrier-associated membrane protein 5	CBL_PTK	217:227	NQPQTQYSATP	CBL	0.8493	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons