DegronMD - Q8TAM1(BBS10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D515Y	TCGA-06-1805	GBM	TCGA	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation rewiring degron network	0.25
p.D515Y	DO11567	GBM	ICGC	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation rewiring degron network	0.25
p.T522M	TCGA-2W-A8YY	CESC	TCGA	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation rewiring degron network	0.0556
p.T522M	DO223732	CESC	ICGC	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation rewiring degron network	0.0556
p.T522M	SIDM01619	Endometrial Carcinoma	GDSC	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation rewiring degron network	0.0556
p.T522M	ACH-000984	Endometrial/Uterine Cancer	CCLE	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation rewiring degron network	0.0556
p.D515N	TCGA-C5-A1BK	CESC	TCGA	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation rewiring degron network	0.25
p.D515N	DO6266	CESC	ICGC	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation rewiring degron network	0.25
p.P505T	TCGA-D1-A17Q	UCEC	TCGA	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation altering degron motif	0.7031
p.P505T	DO41903	UCEC	ICGC	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation altering degron motif	0.7031
p.P505S	TCGA-EE-A2A2	SKCM	TCGA	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation altering degron motif	0.6752
p.P505S	TCGA-FR-A726	SKCM	TCGA	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation altering degron motif	0.6752
p.P505S	DO37583	SKCM	ICGC	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation altering degron motif	0.6752
p.P505S	DO48665	SKCM	ICGC	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation altering degron motif	0.6752
p.T508N	SIDM02027	Colorectal Carcinoma	GDSC	PYSTPTLT	DEG_SCF_FBW7_1	505:512	Mutation altering degron motif	0.7055

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons