DegronMD

Uniprot ID: Q8TAM1

Source protein: Bardet-Biedl syndrome 10 protein

Source gene: BBS10

Class: DEG_SCF_FBW7_1

Location: 505:512

E3 ligase: FBXW7

DEGRON score: 0.9851

ASA_SCORE: 81.5625

COIL: 0.7606

CONS_SCORE: 0.2161

DSS_SCORE: 0.3475

HELIX: 0.0403

FCONS_SCORE: 0.9664

RIG_SCORE: 0.7773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D515Y	TCGA-06-1805	GBM	TCGA	PYSTPTLT	DEG_SCF_FBW7_1	0.25
p.D515Y	DO11567	GBM	ICGC	PYSTPTLT	DEG_SCF_FBW7_1	0.25
p.T522M	TCGA-2W-A8YY	CESC	TCGA	PYSTPTLT	DEG_SCF_FBW7_1	0.0556
p.T522M	DO223732	CESC	ICGC	PYSTPTLT	DEG_SCF_FBW7_1	0.0556
p.T522M	SIDM01619	Endometrial Carcinoma	GDSC	PYSTPTLT	DEG_SCF_FBW7_1	0.0556
p.T522M	ACH-000984	Endometrial/Uterine Cancer	CCLE	PYSTPTLT	DEG_SCF_FBW7_1	0.0556
p.D515N	TCGA-C5-A1BK	CESC	TCGA	PYSTPTLT	DEG_SCF_FBW7_1	0.25
p.D515N	DO6266	CESC	ICGC	PYSTPTLT	DEG_SCF_FBW7_1	0.25
p.P505T	TCGA-D1-A17Q	UCEC	TCGA	PYSTPTLT	DEG_SCF_FBW7_1	0.7031
p.P505T	DO41903	UCEC	ICGC	PYSTPTLT	DEG_SCF_FBW7_1	0.7031
p.P505S	TCGA-EE-A2A2	SKCM	TCGA	PYSTPTLT	DEG_SCF_FBW7_1	0.6752
p.P505S	TCGA-FR-A726	SKCM	TCGA	PYSTPTLT	DEG_SCF_FBW7_1	0.6752
p.P505S	DO37583	SKCM	ICGC	PYSTPTLT	DEG_SCF_FBW7_1	0.6752
p.P505S	DO48665	SKCM	ICGC	PYSTPTLT	DEG_SCF_FBW7_1	0.6752
p.T508N	SIDM02027	Colorectal Carcinoma	GDSC	PYSTPTLT	DEG_SCF_FBW7_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TAM1	Bardet-Biedl syndrome 10 protein	DEG_SCF_FBW7_1	505:512	PYSTPTLT	FBXW7	0.9851	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons