DegronMD - Q8TB45(DEPTOR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q216H	TCGA-AX-A2HC	UCEC	TCGA	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.1389
p.R225Q	TCGA-FS-A1Z0	SKCM	TCGA	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation altering degron motif	0.6218
p.K228N	DO9002	COAD	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation altering degron motif	0.6918
p.K228N	DO16256	KIRC	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation altering degron motif	0.6918
p.P224L	DO7810	COAD	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation altering degron motif	0.7582
p.P224L	DO218089	GACA	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation altering degron motif	0.7582
p.P224L	DO37839	SKCM	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation altering degron motif	0.7582
p.G238C	DO229038	LICA	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.1389
p.G238C	DO229008	LICA	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.1389
p.F230Y	DO45123	LIRI	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation altering degron motif	0.7528
p.V237F	DO25985	LUAD	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation blocking phosphorylation signal	0.6111
p.P224S	DO37790	SKCM	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation altering degron motif	0.6752
p.G222V	DO38016	SKCM	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.3056
p.D235G	DO42592	UCEC	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation blocking phosphorylation signal	0.6667
p.A236V	DO41524	UCEC	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.1944
p.A236V	KMRC-1	kidney	COSMIC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.1944
p.A236V	KYSE-510	oesophagus	COSMIC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.1944
p.V213G	DO41331	UCEC	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.0556
p.Q239K	SIDM00330	Neuroblastoma	GDSC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.1111
p.Q239K	ACH-001355	Neuroblastoma	CCLE	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.1111
p.Q239K	LAN-6	autonomic ganglia	COSMIC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.1111
p.R222G	SIDM01040	Ovarian Carcinoma	GDSC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.3056
p.R222G	ACH-000574	Ovarian Cancer	CCLE	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.3056
p.R222G	FU-OV-1	ovary	COSMIC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.3056
p.R222Q	SIDM00660	Colorectal Carcinoma	GDSC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.3056
p.R222Q	ACH-000985	Colon/Colorectal Cancer	CCLE	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.3056
p.R223W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation altering degron motif	0.7523
p.R223W	ACH-000980	Lung Cancer	CCLE	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation altering degron motif	0.7523
p.R223W	NCI-H1155	lung	COSMIC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation altering degron motif	0.7523
p.N220I	SIDM00149	Melanoma	GDSC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.25
p.N220I	ACH-000750	Skin Cancer	CCLE	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.25
p.N220I	LOXIMVI	skin	COSMIC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.25
p.A236T	Farage	haematopoietic and lymphoid tissue	COSMIC	RRRRLMELL	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.1944

Kaplan plot for DEPTOR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DEPTOR

UniProt ID: Q8TB45

Entrez ID: 64798

Protein name: DEP domain-containing mTOR-interacting protein (DEP domain-containing protein 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DEPTOR in