DegronMD

Uniprot ID: Q8TB45

Source protein: DEP domain-containing mTOR-interacting protein

Source gene: DEPTOR

Class: DEG_APCC_DBOX_1

Location: 223:231

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9579

ASA_SCORE: 88.5889

COIL: 0.3642

CONS_SCORE: 0.4441

DSS_SCORE: 0.3662

HELIX: 0.484

FCONS_SCORE: 1.0059

RIG_SCORE: 0.8022

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q216H	TCGA-AX-A2HC	UCEC	TCGA	RRRRLMELL	DEG_APCC_DBOX_1	0.1389
p.R225Q	TCGA-FS-A1Z0	SKCM	TCGA	RRRRLMELL	DEG_APCC_DBOX_1	0.6218
p.K228N	DO9002	COAD	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	0.6918
p.K228N	DO16256	KIRC	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	0.6918
p.P224L	DO7810	COAD	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	0.7582
p.P224L	DO218089	GACA	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	0.7582
p.P224L	DO37839	SKCM	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	0.7582
p.G238C	DO229038	LICA	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	0.1389
p.G238C	DO229008	LICA	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	0.1389
p.F230Y	DO45123	LIRI	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	0.7528
p.V237F	DO25985	LUAD	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	0.6111
p.P224S	DO37790	SKCM	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	0.6752
p.G222V	DO38016	SKCM	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	0.3056
p.D235G	DO42592	UCEC	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	0.6667
p.A236V	DO41524	UCEC	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	0.1944
p.A236V	KMRC-1	kidney	COSMIC	RRRRLMELL	DEG_APCC_DBOX_1	0.1944
p.A236V	KYSE-510	oesophagus	COSMIC	RRRRLMELL	DEG_APCC_DBOX_1	0.1944
p.V213G	DO41331	UCEC	ICGC	RRRRLMELL	DEG_APCC_DBOX_1	0.0556
p.Q239K	SIDM00330	Neuroblastoma	GDSC	RRRRLMELL	DEG_APCC_DBOX_1	0.1111
p.Q239K	ACH-001355	Neuroblastoma	CCLE	RRRRLMELL	DEG_APCC_DBOX_1	0.1111
p.Q239K	LAN-6	autonomic_ganglia	COSMIC	RRRRLMELL	DEG_APCC_DBOX_1	0.1111
p.R222G	SIDM01040	Ovarian Carcinoma	GDSC	RRRRLMELL	DEG_APCC_DBOX_1	0.3056
p.R222G	ACH-000574	Ovarian Cancer	CCLE	RRRRLMELL	DEG_APCC_DBOX_1	0.3056
p.R222G	FU-OV-1	ovary	COSMIC	RRRRLMELL	DEG_APCC_DBOX_1	0.3056
p.R222Q	SIDM00660	Colorectal Carcinoma	GDSC	RRRRLMELL	DEG_APCC_DBOX_1	0.3056
p.R222Q	ACH-000985	Colon/Colorectal Cancer	CCLE	RRRRLMELL	DEG_APCC_DBOX_1	0.3056
p.R223W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	RRRRLMELL	DEG_APCC_DBOX_1	0.7523
p.R223W	ACH-000980	Lung Cancer	CCLE	RRRRLMELL	DEG_APCC_DBOX_1	0.7523
p.R223W	NCI-H1155	lung	COSMIC	RRRRLMELL	DEG_APCC_DBOX_1	0.7523
p.N220I	SIDM00149	Melanoma	GDSC	RRRRLMELL	DEG_APCC_DBOX_1	0.25
p.N220I	ACH-000750	Skin Cancer	CCLE	RRRRLMELL	DEG_APCC_DBOX_1	0.25
p.N220I	LOXIMVI	skin	COSMIC	RRRRLMELL	DEG_APCC_DBOX_1	0.25
p.A236T	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	RRRRLMELL	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRRLMELL

Degron related mutations and impact score

Drug responses associated with DEPTOR mutations

All proteins holding degron of RRRRLMELL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TB45	DEP domain-containing mTOR-interacting protein	DEG_APCC_DBOX_1	223:231	RRRRLMELL	APC,CDC20,FZR1	0.9579	More...