DegronMD - Q8TBK2(SETD6)

SETD6

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M296T	TCGA-32-1982	GBM	TCGA	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.2222
p.N306S	TCGA-CV-7104	HNSC	TCGA	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.3056
p.P302Q	TCGA-D3-A3CE	SKCM	TCGA	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation altering degron motif	0.7035
p.P302Q	TCGA-FS-A1ZB	SKCM	TCGA	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation altering degron motif	0.7035
p.H309N	DO225223	BRCA	ICGC	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.2222
p.R295C	DO7783	COAD	ICGC	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.1944
p.R295C	ACH-001182	Unknown	CCLE	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.1944
p.R295C	RPMI-6666	haematopoietic and lymphoid tissue	COSMIC	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.1944
p.R295H	DO234260	ESAD	ICGC	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.1944
p.L299V	DO23168	LINC	ICGC	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.3056
p.R314C	DO41584	UCEC	ICGC	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.0833
p.R314H	DO41109	UCEC	ICGC	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.0833
p.H295D	MZ2-MEL	skin	COSMIC	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.1944
p.E291A	SNU-175	large intestine	COSMIC	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.0833
p.E296Q	LXF-289	lung	COSMIC	VEPYPD	LIG_APCC_ABBA_1	300:305	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc