DegronMD

Uniprot ID: Q8TBK2

Source protein: N-lysine methyltransferase SETD6

Source gene: SETD6

Class: LIG_APCC_ABBA_1

Location: 300:305

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9787

ASA_SCORE: 69.0833

COIL: 0.805

CONS_SCORE: 0.4644

DSS_SCORE: 0.3044

HELIX: 0.0162

FCONS_SCORE: 0.8046

RIG_SCORE: 0.7786

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M296T	TCGA-32-1982	GBM	TCGA	VEPYPD	LIG_APCC_ABBA_1	0.2222
p.N306S	TCGA-CV-7104	HNSC	TCGA	VEPYPD	LIG_APCC_ABBA_1	0.3056
p.P302Q	TCGA-D3-A3CE	SKCM	TCGA	VEPYPD	LIG_APCC_ABBA_1	0.7035
p.P302Q	TCGA-FS-A1ZB	SKCM	TCGA	VEPYPD	LIG_APCC_ABBA_1	0.7035
p.H309N	DO225223	BRCA	ICGC	VEPYPD	LIG_APCC_ABBA_1	0.2222
p.R295C	DO7783	COAD	ICGC	VEPYPD	LIG_APCC_ABBA_1	0.1944
p.R295C	ACH-001182	Unknown	CCLE	VEPYPD	LIG_APCC_ABBA_1	0.1944
p.R295C	RPMI-6666	haematopoietic_and_lymphoid_tissue	COSMIC	VEPYPD	LIG_APCC_ABBA_1	0.1944
p.R295H	DO234260	ESAD	ICGC	VEPYPD	LIG_APCC_ABBA_1	0.1944
p.L299V	DO23168	LINC	ICGC	VEPYPD	LIG_APCC_ABBA_1	0.3056
p.R314C	DO41584	UCEC	ICGC	VEPYPD	LIG_APCC_ABBA_1	0.0833
p.R314H	DO41109	UCEC	ICGC	VEPYPD	LIG_APCC_ABBA_1	0.0833
p.H295D	MZ2-MEL	skin	COSMIC	VEPYPD	LIG_APCC_ABBA_1	0.1944
p.E291A	SNU-175	large_intestine	COSMIC	VEPYPD	LIG_APCC_ABBA_1	0.0833
p.E296Q	LXF-289	lung	COSMIC	VEPYPD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBK2	N-lysine methyltransferase SETD6	LIG_APCC_ABBA_1	300:305	VEPYPD	APC,CDC20,FZR1	0.9787	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons