DegronMD - Q8TBM8(DNAJB14)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M289I	TCGA-17-Z053	LUAD	TCGA	NPPYSLYP	CBL_PTK	272:279	Mutation rewiring degron network	0.0556
p.P274H	TCGA-A5-A0G2	UCEC	TCGA	NPPYSLYP	CBL_PTK	272:279	Mutation altering degron motif	0.6583
p.P274H	DO229018	LICA	ICGC	NPPYSLYP	CBL_PTK	272:279	Mutation altering degron motif	0.6583
p.P274H	DO41235	UCEC	ICGC	NPPYSLYP	CBL_PTK	272:279	Mutation altering degron motif	0.6583
p.S281F	TCGA-AX-A05Z	UCEC	TCGA	NPPYSLYP	CBL_PTK	272:279	Mutation rewiring degron network	0.2778
p.S281F	DO40884	UCEC	ICGC	NPPYSLYP	CBL_PTK	272:279	Mutation rewiring degron network	0.2778
p.P279H	TCGA-AX-A1CE	UCEC	TCGA	NPPYSLYP	CBL_PTK	272:279	Mutation altering degron motif	0.7694
p.P279H	DO42280	UCEC	ICGC	NPPYSLYP	CBL_PTK	272:279	Mutation altering degron motif	0.7694
p.V262M	TCGA-VQ-A8P2	STAD	TCGA	NPPYSLYP	CBL_PTK	272:279	Mutation rewiring degron network	0.0556
p.V262M	DO51761	STAD	ICGC	NPPYSLYP	CBL_PTK	272:279	Mutation rewiring degron network	0.0556

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons