DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NPPYSLYP
Uniprot ID:
Q8TBM8
Source protein:
DnaJ homolog subfamily B member 14
Source gene:
DNAJB14
Class:
CBL_PTK
Location:
272:279
E3 ligase:
CBL
DEGRON score:
0.781
ASA_SCORE:
80.15
COIL:
0.8881
CONS_SCORE:
0.4963
DSS_SCORE:
0.1866
HELIX:
0.0399
FCONS_SCORE:
1.1616
RIG_SCORE:
0.7697
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.M289I
TCGA-17-Z053
LUAD
TCGA
NPPYSLYP
CBL_PTK
0.0556
p.P274H
TCGA-A5-A0G2
UCEC
TCGA
NPPYSLYP
CBL_PTK
0.6583
p.P274H
DO229018
LICA
ICGC
NPPYSLYP
CBL_PTK
0.6583
p.P274H
DO41235
UCEC
ICGC
NPPYSLYP
CBL_PTK
0.6583
p.S281F
TCGA-AX-A05Z
UCEC
TCGA
NPPYSLYP
CBL_PTK
0.2778
p.S281F
DO40884
UCEC
ICGC
NPPYSLYP
CBL_PTK
0.2778
p.P279H
TCGA-AX-A1CE
UCEC
TCGA
NPPYSLYP
CBL_PTK
0.7694
p.P279H
DO42280
UCEC
ICGC
NPPYSLYP
CBL_PTK
0.7694
p.V262M
TCGA-VQ-A8P2
STAD
TCGA
NPPYSLYP
CBL_PTK
0.0556
p.V262M
DO51761
STAD
ICGC
NPPYSLYP
CBL_PTK
0.0556
Drug responses associated with DNAJB14 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NPPYSLYP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8TBM8
DnaJ homolog subfamily B member 14
CBL_PTK
272:279
NPPYSLYP
CBL
0.781
More...
