DegronMD - Q8TBZ6(TRMT10A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P338R	TCGA-05-4410	LUAD	TCGA	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.0833
p.P338R	DO25426	LUAD	ICGC	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.0833
p.K323R	TCGA-A4-7288	KIRP	TCGA	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.2778
p.K323R	DO20925	KIRP	ICGC	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.2778
p.S336F	TCGA-AA-A010	COAD	TCGA	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.5833
p.S332Y	TCGA-BG-A221	UCEC	TCGA	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.25
p.S332Y	DO42384	UCEC	ICGC	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.25
p.T330I	TCGA-IB-7651	PAAD	TCGA	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.3056
p.T330I	DO46657	PAAD	ICGC	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.3056
p.E322Q	TCGA-N5-A4RF	UCS	TCGA	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.25
p.L316I	DO229037	LICA	ICGC	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.0833
p.H320R	DO51130	PRAD	ICGC	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.1944
p.E327K	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation altering degron motif	0.7022
p.E327K	ACH-000904	Lung Cancer	CCLE	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation altering degron motif	0.7022
p.E327K	ACH-001362	Lung Cancer	CCLE	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation altering degron motif	0.7022
p.E327K	NCI-H1770	lung	COSMIC	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation altering degron motif	0.7022
p.P319L	SIDM00217	Colorectal Carcinoma	GDSC	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.1667
p.P319L	ACH-000999	Colon/Colorectal Cancer	CCLE	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.1667
p.P319L	SNU-1040	large intestine	COSMIC	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.1667
p.E321A	ACH-001119	Lymphoma	CCLE	DKENH	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.2222

Kaplan plot for TRMT10A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRMT10A

UniProt ID: Q8TBZ6

Entrez ID: 93587

Protein name: tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRMT10A in