DegronMD

Uniprot ID: Q8TBZ6

Source protein: tRNA methyltransferase 10 homolog A

Source gene: TRMT10A

Class: DEG_APCC_KENBOX_2

Location: 325:329

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9517

ASA_SCORE: 118.48

COIL: 0.664

CONS_SCORE: 0.3487

DSS_SCORE: 0.8361

HELIX: 0.3204

FCONS_SCORE: 1.0271

RIG_SCORE: 0.5825

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P338R	TCGA-05-4410	LUAD	TCGA	DKENH	DEG_APCC_KENBOX_2	0.0833
p.P338R	DO25426	LUAD	ICGC	DKENH	DEG_APCC_KENBOX_2	0.0833
p.K323R	TCGA-A4-7288	KIRP	TCGA	DKENH	DEG_APCC_KENBOX_2	0.2778
p.K323R	DO20925	KIRP	ICGC	DKENH	DEG_APCC_KENBOX_2	0.2778
p.S336F	TCGA-AA-A010	COAD	TCGA	DKENH	DEG_APCC_KENBOX_2	0.5833
p.S332Y	TCGA-BG-A221	UCEC	TCGA	DKENH	DEG_APCC_KENBOX_2	0.25
p.S332Y	DO42384	UCEC	ICGC	DKENH	DEG_APCC_KENBOX_2	0.25
p.T330I	TCGA-IB-7651	PAAD	TCGA	DKENH	DEG_APCC_KENBOX_2	0.3056
p.T330I	DO46657	PAAD	ICGC	DKENH	DEG_APCC_KENBOX_2	0.3056
p.E322Q	TCGA-N5-A4RF	UCS	TCGA	DKENH	DEG_APCC_KENBOX_2	0.25
p.L316I	DO229037	LICA	ICGC	DKENH	DEG_APCC_KENBOX_2	0.0833
p.H320R	DO51130	PRAD	ICGC	DKENH	DEG_APCC_KENBOX_2	0.1944
p.E327K	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	DKENH	DEG_APCC_KENBOX_2	0.7022
p.E327K	ACH-000904	Lung Cancer	CCLE	DKENH	DEG_APCC_KENBOX_2	0.7022
p.E327K	ACH-001362	Lung Cancer	CCLE	DKENH	DEG_APCC_KENBOX_2	0.7022
p.E327K	NCI-H1770	lung	COSMIC	DKENH	DEG_APCC_KENBOX_2	0.7022
p.P319L	SIDM00217	Colorectal Carcinoma	GDSC	DKENH	DEG_APCC_KENBOX_2	0.1667
p.P319L	ACH-000999	Colon/Colorectal Cancer	CCLE	DKENH	DEG_APCC_KENBOX_2	0.1667
p.P319L	SNU-1040	large_intestine	COSMIC	DKENH	DEG_APCC_KENBOX_2	0.1667
p.E321A	ACH-001119	Lymphoma	CCLE	DKENH	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBZ6	tRNA methyltransferase 10 homolog A	DEG_APCC_KENBOX_2	325:329	DKENH	APC,CDC20,FZR1	0.9517	More...
Q8WY54	Protein phosphatase 1E	DEG_APCC_KENBOX_2	518:522	DKENH	APC,CDC20,FZR1	0.5995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons