DegronMD - Q8WY54(PPM1E)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G523V	TCGA-24-2280	OV	TCGA	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation rewiring degron network	0.3056
p.G523V	DO28511	OV	ICGC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation rewiring degron network	0.3056
p.R527H	TCGA-AJ-A3EL	UCEC	TCGA	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation rewiring degron network	0.1944
p.R527H	DO41542	UCEC	ICGC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation rewiring degron network	0.1944
p.R527H	SIDM00857	Melanoma	GDSC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation rewiring degron network	0.1944
p.R527H	ACH-000572	Skin Cancer	CCLE	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation rewiring degron network	0.1944
p.R527H	G-361	skin	COSMIC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation rewiring degron network	0.1944
p.Q509E	TCGA-EK-A2H0	CESC	TCGA	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation rewiring degron network	0.0833
p.Q509E	DO49020	CESC	ICGC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation rewiring degron network	0.0833
p.G510E	TCGA-WE-A8K4	SKCM	TCGA	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation blocking phosphorylation signal	0.5556
p.G510E	DO222824	MELA	ICGC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation blocking phosphorylation signal	0.5556
p.G510E	DO51281	SKCM	ICGC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation blocking phosphorylation signal	0.5556
p.E524K	DO233825	GACA	ICGC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation rewiring degron network	0.2778
p.W529C	DO229019	LICA	ICGC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation rewiring degron network	0.1389
p.N521T	SIDM00845	Burkitt's Lymphoma	GDSC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation altering degron motif	0.7055
p.N521T	SIDM00461	Acute Myeloid Leukemia	GDSC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation altering degron motif	0.7055
p.N521T	SIDM01519	Head and Neck Carcinoma	GDSC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation altering degron motif	0.7055
p.N521T	ACH-000786	Lymphoma	CCLE	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation altering degron motif	0.7055
p.N521T	Daudi	haematopoietic and lymphoid tissue	COSMIC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation altering degron motif	0.7055
p.N521T	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation altering degron motif	0.7055
p.E520K	SIDM01105	Melanoma	GDSC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation altering degron motif	0.7022
p.E520K	ACH-000423	Skin Cancer	CCLE	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation altering degron motif	0.7022
p.E520K	SK-MEL-3	skin	COSMIC	DKENH	DEG_APCC_KENBOX_2	518:522	Mutation altering degron motif	0.7022

Kaplan plot for PPM1E in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPM1E

UniProt ID: Q8WY54

Entrez ID: 22843

Protein name: Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPM1E in