DegronMD

Uniprot ID: Q8WY54

Source protein: Protein phosphatase 1E

Source gene: PPM1E

Class: DEG_APCC_KENBOX_2

Location: 518:522

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5995

ASA_SCORE: 99.52

COIL: 0.7394

CONS_SCORE: 0.2073

DSS_SCORE: 0.6888

HELIX: 0.2186

FCONS_SCORE: 0.9668

RIG_SCORE: 0.6107

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G523V	TCGA-24-2280	OV	TCGA	DKENH	DEG_APCC_KENBOX_2	0.3056
p.G523V	DO28511	OV	ICGC	DKENH	DEG_APCC_KENBOX_2	0.3056
p.R527H	TCGA-AJ-A3EL	UCEC	TCGA	DKENH	DEG_APCC_KENBOX_2	0.1944
p.R527H	DO41542	UCEC	ICGC	DKENH	DEG_APCC_KENBOX_2	0.1944
p.R527H	SIDM00857	Melanoma	GDSC	DKENH	DEG_APCC_KENBOX_2	0.1944
p.R527H	ACH-000572	Skin Cancer	CCLE	DKENH	DEG_APCC_KENBOX_2	0.1944
p.R527H	G-361	skin	COSMIC	DKENH	DEG_APCC_KENBOX_2	0.1944
p.Q509E	TCGA-EK-A2H0	CESC	TCGA	DKENH	DEG_APCC_KENBOX_2	0.0833
p.Q509E	DO49020	CESC	ICGC	DKENH	DEG_APCC_KENBOX_2	0.0833
p.G510E	TCGA-WE-A8K4	SKCM	TCGA	DKENH	DEG_APCC_KENBOX_2	0.5556
p.G510E	DO222824	MELA	ICGC	DKENH	DEG_APCC_KENBOX_2	0.5556
p.G510E	DO51281	SKCM	ICGC	DKENH	DEG_APCC_KENBOX_2	0.5556
p.E524K	DO233825	GACA	ICGC	DKENH	DEG_APCC_KENBOX_2	0.2778
p.W529C	DO229019	LICA	ICGC	DKENH	DEG_APCC_KENBOX_2	0.1389
p.N521T	SIDM00845	Burkitt's Lymphoma	GDSC	DKENH	DEG_APCC_KENBOX_2	0.7055
p.N521T	SIDM00461	Acute Myeloid Leukemia	GDSC	DKENH	DEG_APCC_KENBOX_2	0.7055
p.N521T	SIDM01519	Head and Neck Carcinoma	GDSC	DKENH	DEG_APCC_KENBOX_2	0.7055
p.N521T	ACH-000786	Lymphoma	CCLE	DKENH	DEG_APCC_KENBOX_2	0.7055
p.N521T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DKENH	DEG_APCC_KENBOX_2	0.7055
p.N521T	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	DKENH	DEG_APCC_KENBOX_2	0.7055
p.E520K	SIDM01105	Melanoma	GDSC	DKENH	DEG_APCC_KENBOX_2	0.7022
p.E520K	ACH-000423	Skin Cancer	CCLE	DKENH	DEG_APCC_KENBOX_2	0.7022
p.E520K	SK-MEL-3	skin	COSMIC	DKENH	DEG_APCC_KENBOX_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBZ6	tRNA methyltransferase 10 homolog A	DEG_APCC_KENBOX_2	325:329	DKENH	APC,CDC20,FZR1	0.9517	More...
Q8WY54	Protein phosphatase 1E	DEG_APCC_KENBOX_2	518:522	DKENH	APC,CDC20,FZR1	0.5995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons