DegronMD - Q8TC07(TBC1D15)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V642F	TCGA-21-1082	LUSC	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation rewiring degron network	0.1667
p.P654A	TCGA-69-7978	LUAD	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation altering degron motif	0.6392
p.D645Y	TCGA-AX-A2HC	UCEC	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation rewiring degron network	0.25
p.D639Y	TCGA-AX-A2HD	UCEC	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation rewiring degron network	0.0833
p.P652A	TCGA-B5-A11R	UCEC	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation altering degron motif	0.7503
p.V648F	TCGA-DU-5870	LGG	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation altering degron motif	0.7068
p.E646K	TCGA-E6-A1LX	UCEC	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation rewiring degron network	0.2778
p.P652S	TCGA-FW-A3R5	SKCM	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation altering degron motif	0.6752
p.S640L	TCGA-G2-A2EO	BLCA	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation blocking phosphorylation signal	0.5556
p.Q659H	TCGA-GN-A8LK	SKCM	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation rewiring degron network	0.2222
p.L663F	TCGA-GU-A767	BLCA	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation rewiring degron network	0.1111
p.V649I	SIDM01090	Colorectal Carcinoma	GDSC	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation altering degron motif	0.5965
p.V649I	RKO	large intestine	COSMIC	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation altering degron motif	0.5965
p.P652R	SIDM01190	Bladder Carcinoma	GDSC	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation altering degron motif	0.7512
p.P652R	TCCSUP	urinary tract	COSMIC	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation altering degron motif	0.7512
p.T660K	ACH-000395	Lung Cancer	CCLE	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation blocking phosphorylation signal	0.6389
p.T660K	NCI-H520	lung	COSMIC	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation blocking phosphorylation signal	0.6389
p.A645V	ACH-002021	Endometrial/Uterine Cancer	CCLE	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation rewiring degron network	0.25
p.V640I	RKO	large intestine	COSMIC	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation blocking phosphorylation signal	0.5556
p.P643R	TCCSUP	urinary tract	COSMIC	VVMTPCPT	DEG_SCF_FBW7_1	648:655	Mutation rewiring degron network	0.1944

Kaplan plot for TBC1D15 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBC1D15

UniProt ID: Q8TC07

Entrez ID: 64786

Protein name: TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TBC1D15 in