DegronMD

Uniprot ID: Q8TC07

Source protein: TBC1 domain family member 15

Source gene: TBC1D15

Class: DEG_SCF_FBW7_1

Location: 648:655

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 81.125

COIL: 0.8961

CONS_SCORE: 0.2874

DSS_SCORE: 0.5558

HELIX: 0.0376

FCONS_SCORE: 1.0274

RIG_SCORE: 0.7773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V642F	TCGA-21-1082	LUSC	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	0.1667
p.P654A	TCGA-69-7978	LUAD	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	0.6392
p.D645Y	TCGA-AX-A2HC	UCEC	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	0.25
p.D639Y	TCGA-AX-A2HD	UCEC	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	0.0833
p.P652A	TCGA-B5-A11R	UCEC	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	0.7503
p.V648F	TCGA-DU-5870	LGG	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	0.7068
p.E646K	TCGA-E6-A1LX	UCEC	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	0.2778
p.P652S	TCGA-FW-A3R5	SKCM	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	0.6752
p.S640L	TCGA-G2-A2EO	BLCA	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	0.5556
p.Q659H	TCGA-GN-A8LK	SKCM	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	0.2222
p.L663F	TCGA-GU-A767	BLCA	TCGA	VVMTPCPT	DEG_SCF_FBW7_1	0.1111
p.V649I	SIDM01090	Colorectal Carcinoma	GDSC	VVMTPCPT	DEG_SCF_FBW7_1	0.5965
p.V649I	RKO	large_intestine	COSMIC	VVMTPCPT	DEG_SCF_FBW7_1	0.5965
p.P652R	SIDM01190	Bladder Carcinoma	GDSC	VVMTPCPT	DEG_SCF_FBW7_1	0.7512
p.P652R	TCCSUP	urinary_tract	COSMIC	VVMTPCPT	DEG_SCF_FBW7_1	0.7512
p.T660K	ACH-000395	Lung Cancer	CCLE	VVMTPCPT	DEG_SCF_FBW7_1	0.6389
p.T660K	NCI-H520	lung	COSMIC	VVMTPCPT	DEG_SCF_FBW7_1	0.6389
p.A645V	ACH-002021	Endometrial/Uterine Cancer	CCLE	VVMTPCPT	DEG_SCF_FBW7_1	0.25
p.V640I	RKO	large_intestine	COSMIC	VVMTPCPT	DEG_SCF_FBW7_1	0.5556
p.P643R	TCCSUP	urinary_tract	COSMIC	VVMTPCPT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TC07	TBC1 domain family member 15	DEG_SCF_FBW7_1	648:655	VVMTPCPT	FBXW7	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons