DegronMD - Q8TD08(MAPK15)

FUNCTION: Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:22948227, PubMed:24618899, PubMed:29021280, PubMed:21847093, PubMed:20733054). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:20638370, PubMed:19166846). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R262Q	TCGA-CN-6016	HNSC	TCGA	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.7329
p.R262Q	DO14470	HNSC	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.7329
p.P271S	TCGA-DI-A1BU	UCEC	TCGA	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.2778
p.P271S	DO42023	UCEC	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.2778
p.D266H	TCGA-E7-A7DV	BLCA	TCGA	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6577
p.D266H	DO48583	BLCA	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6577
p.R260W	TCGA-EO-A22U	UCEC	TCGA	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.3056
p.R260W	DO230529	LUSC	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.3056
p.R260W	DO43755	UCEC	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.3056
p.R260W	SIDM01107	Melanoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.3056
p.T264M	DO233760	GACA	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6312
p.T264M	DO233884	GACA	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6312
p.T264M	SIDM01020	Plasma Cell Myeloma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6312
p.T264M	SIDM00570	Gastric Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6312
p.T264M	SIDM00993	Plasma Cell Myeloma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6312
p.T264M	SIDM00611	Kidney Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6312
p.T264M	SIDM00544	Neuroblastoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6312
p.T264M	SIDM00555	Glioblastoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6312
p.T264M	SIDM01005	Acute Myeloid Leukemia	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6312
p.T264M	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6312
p.T264M	SIDM00487	Colorectal Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6312
p.T264M	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6312
p.T264M	SIDM01335	Kidney Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6312
p.T264M	SIDM01460	Glioma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6312
p.E276K	DO45299	LIRI	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.1389
p.P261T	DO232224	PBCA	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.5919
p.L268I	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6063
p.L268I	ACH-000945	Lung Cancer	CCLE	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6063
p.L268I	NCI-H650	lung	COSMIC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation altering degron motif	0.6063
p.T273A	SIDM01159	Other Sarcomas	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.2222
p.S274F	SIDM00056	Thyroid Gland Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.1944
p.S274F	ACH-002148	Thyroid Cancer	CCLE	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.1944
p.S274F	K5	thyroid	COSMIC	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.1944
p.P270L	ACH-000973	Bladder Cancer	CCLE	PRQTLDALL	DEG_APCC_DBOX_1	261:269	Mutation rewiring degron network	0.3056

Kaplan plot for MAPK15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAPK15

UniProt ID: Q8TD08

Entrez ID: 225689

Protein name: Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAPK15 in