DegronMD

Uniprot ID: Q8TD08

Source protein: Mitogen-activated protein kinase 15

Source gene: MAPK15

Class: DEG_APCC_DBOX_1

Location: 261:269

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7954

ASA_SCORE: 67.1778

COIL: 0.6207

CONS_SCORE: 0.5455

DSS_SCORE: 0.4895

HELIX: 0.358

FCONS_SCORE: 1.0691

RIG_SCORE: 0.7222

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R262Q	TCGA-CN-6016	HNSC	TCGA	PRQTLDALL	DEG_APCC_DBOX_1	0.7329
p.R262Q	DO14470	HNSC	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	0.7329
p.P271S	TCGA-DI-A1BU	UCEC	TCGA	PRQTLDALL	DEG_APCC_DBOX_1	0.2778
p.P271S	DO42023	UCEC	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	0.2778
p.D266H	TCGA-E7-A7DV	BLCA	TCGA	PRQTLDALL	DEG_APCC_DBOX_1	0.6577
p.D266H	DO48583	BLCA	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	0.6577
p.R260W	TCGA-EO-A22U	UCEC	TCGA	PRQTLDALL	DEG_APCC_DBOX_1	0.3056
p.R260W	DO230529	LUSC	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	0.3056
p.R260W	DO43755	UCEC	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	0.3056
p.R260W	SIDM01107	Melanoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.3056
p.T264M	DO233760	GACA	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	0.6312
p.T264M	DO233884	GACA	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	0.6312
p.T264M	SIDM01020	Plasma Cell Myeloma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.6312
p.T264M	SIDM00570	Gastric Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.6312
p.T264M	SIDM00993	Plasma Cell Myeloma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.6312
p.T264M	SIDM00611	Kidney Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.6312
p.T264M	SIDM00544	Neuroblastoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.6312
p.T264M	SIDM00555	Glioblastoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.6312
p.T264M	SIDM01005	Acute Myeloid Leukemia	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.6312
p.T264M	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.6312
p.T264M	SIDM00487	Colorectal Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.6312
p.T264M	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.6312
p.T264M	SIDM01335	Kidney Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.6312
p.T264M	SIDM01460	Glioma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.6312
p.E276K	DO45299	LIRI	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	0.1389
p.P261T	DO232224	PBCA	ICGC	PRQTLDALL	DEG_APCC_DBOX_1	0.5919
p.L268I	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.6063
p.L268I	ACH-000945	Lung Cancer	CCLE	PRQTLDALL	DEG_APCC_DBOX_1	0.6063
p.L268I	NCI-H650	lung	COSMIC	PRQTLDALL	DEG_APCC_DBOX_1	0.6063
p.T273A	SIDM01159	Other Sarcomas	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.2222
p.S274F	SIDM00056	Thyroid Gland Carcinoma	GDSC	PRQTLDALL	DEG_APCC_DBOX_1	0.1944
p.S274F	ACH-002148	Thyroid Cancer	CCLE	PRQTLDALL	DEG_APCC_DBOX_1	0.1944
p.S274F	K5	thyroid	COSMIC	PRQTLDALL	DEG_APCC_DBOX_1	0.1944
p.P270L	ACH-000973	Bladder Cancer	CCLE	PRQTLDALL	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRQTLDALL

Degron related mutations and impact score

Drug responses associated with MAPK15 mutations

All proteins holding degron of PRQTLDALL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TD08	Mitogen-activated protein kinase 15	DEG_APCC_DBOX_1	261:269	PRQTLDALL	APC,CDC20,FZR1	0.7954	More...