DegronMD - Q8TD16(BICD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R457H	TCGA-AJ-A3EL	UCEC	TCGA	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.7133
p.R457H	TCGA-AP-A0LM	UCEC	TCGA	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.7133
p.R457H	TCGA-NH-A50V	COAD	TCGA	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.7133
p.R457H	TCGA-XK-AAIW	PRAD	TCGA	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.7133
p.R457H	DO44094	COAD	ICGC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.7133
p.R457H	DO51407	PRAD	ICGC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.7133
p.R457H	DO43306	UCEC	ICGC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.7133
p.R457H	DO41542	UCEC	ICGC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.7133
p.R450C	TCGA-DR-A0ZM	CESC	TCGA	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.8301
p.R450C	TCGA-GN-A8LK	SKCM	TCGA	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.8301
p.R450C	DO6254	CESC	ICGC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.8301
p.R450C	DO51259	SKCM	ICGC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.8301
p.E461K	TCGA-YC-A89H	BLCA	TCGA	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2222
p.E461K	DO51948	BLCA	ICGC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2222
p.E461K	SIDM00259	Neuroblastoma	GDSC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2222
p.E461K	ACH-001369	Ovarian Cancer	CCLE	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2222
p.E461K	ACH-002278	Neuroblastoma	CCLE	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2222
p.E461K	NB10	autonomic ganglia	COSMIC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2222
p.S458N	DO233634	GACA	ICGC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation blocking phosphorylation signal	0.75
p.E445Q	DO45091	LIRI	ICGC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.2222
p.R463C	DO46877	RECA	ICGC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.1667
p.A442V	SIDM01307	Colorectal Carcinoma	GDSC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.1389
p.E464D	SIDM00282	Colorectal Carcinoma	GDSC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.1389
p.E464D	ACH-000998	Colon/Colorectal Cancer	CCLE	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.1389
p.E464D	CW-2	large intestine	COSMIC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation rewiring degron network	0.1389
p.L453F	SIDM01695	Acute Myeloid Leukemia	GDSC	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.6981
p.L453F	ACH-000166	Leukemia	CCLE	LREQLKALR	DEG_APCC_DBOX_1	449:457	Mutation altering degron motif	0.6981

Kaplan plot for BICD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BICD2

UniProt ID: Q8TD16

Entrez ID: 23299

Protein name: Protein bicaudal D homolog 2 (Bic-D 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BICD2 in