DegronMD

Uniprot ID: Q8TD16

Source protein: Protein bicaudal D homolog 2

Source gene: BICD2

Class: DEG_APCC_DBOX_1

Location: 449:457

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9727

ASA_SCORE: 91.4333

COIL: 0.0646

CONS_SCORE: 0.3947

DSS_SCORE: 0.4276

HELIX: 0.9368

FCONS_SCORE: 1.2104

RIG_SCORE: 0.7763

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R457H	TCGA-AJ-A3EL	UCEC	TCGA	LREQLKALR	DEG_APCC_DBOX_1	0.7133
p.R457H	TCGA-AP-A0LM	UCEC	TCGA	LREQLKALR	DEG_APCC_DBOX_1	0.7133
p.R457H	TCGA-NH-A50V	COAD	TCGA	LREQLKALR	DEG_APCC_DBOX_1	0.7133
p.R457H	TCGA-XK-AAIW	PRAD	TCGA	LREQLKALR	DEG_APCC_DBOX_1	0.7133
p.R457H	DO44094	COAD	ICGC	LREQLKALR	DEG_APCC_DBOX_1	0.7133
p.R457H	DO51407	PRAD	ICGC	LREQLKALR	DEG_APCC_DBOX_1	0.7133
p.R457H	DO43306	UCEC	ICGC	LREQLKALR	DEG_APCC_DBOX_1	0.7133
p.R457H	DO41542	UCEC	ICGC	LREQLKALR	DEG_APCC_DBOX_1	0.7133
p.R450C	TCGA-DR-A0ZM	CESC	TCGA	LREQLKALR	DEG_APCC_DBOX_1	0.8301
p.R450C	TCGA-GN-A8LK	SKCM	TCGA	LREQLKALR	DEG_APCC_DBOX_1	0.8301
p.R450C	DO6254	CESC	ICGC	LREQLKALR	DEG_APCC_DBOX_1	0.8301
p.R450C	DO51259	SKCM	ICGC	LREQLKALR	DEG_APCC_DBOX_1	0.8301
p.E461K	TCGA-YC-A89H	BLCA	TCGA	LREQLKALR	DEG_APCC_DBOX_1	0.2222
p.E461K	DO51948	BLCA	ICGC	LREQLKALR	DEG_APCC_DBOX_1	0.2222
p.E461K	SIDM00259	Neuroblastoma	GDSC	LREQLKALR	DEG_APCC_DBOX_1	0.2222
p.E461K	ACH-001369	Ovarian Cancer	CCLE	LREQLKALR	DEG_APCC_DBOX_1	0.2222
p.E461K	ACH-002278	Neuroblastoma	CCLE	LREQLKALR	DEG_APCC_DBOX_1	0.2222
p.E461K	NB10	autonomic_ganglia	COSMIC	LREQLKALR	DEG_APCC_DBOX_1	0.2222
p.S458N	DO233634	GACA	ICGC	LREQLKALR	DEG_APCC_DBOX_1	0.75
p.E445Q	DO45091	LIRI	ICGC	LREQLKALR	DEG_APCC_DBOX_1	0.2222
p.R463C	DO46877	RECA	ICGC	LREQLKALR	DEG_APCC_DBOX_1	0.1667
p.A442V	SIDM01307	Colorectal Carcinoma	GDSC	LREQLKALR	DEG_APCC_DBOX_1	0.1389
p.E464D	SIDM00282	Colorectal Carcinoma	GDSC	LREQLKALR	DEG_APCC_DBOX_1	0.1389
p.E464D	ACH-000998	Colon/Colorectal Cancer	CCLE	LREQLKALR	DEG_APCC_DBOX_1	0.1389
p.E464D	CW-2	large_intestine	COSMIC	LREQLKALR	DEG_APCC_DBOX_1	0.1389
p.L453F	SIDM01695	Acute Myeloid Leukemia	GDSC	LREQLKALR	DEG_APCC_DBOX_1	0.6981
p.L453F	ACH-000166	Leukemia	CCLE	LREQLKALR	DEG_APCC_DBOX_1	0.6981

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LREQLKALR

Degron related mutations and impact score

Drug responses associated with BICD2 mutations

All proteins holding degron of LREQLKALR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TD16	Protein bicaudal D homolog 2	DEG_APCC_DBOX_1	449:457	LREQLKALR	APC,CDC20,FZR1	0.9727	More...