DegronMD - Q8TDI0(CHD5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1891Q	TCGA-2W-A8YY	CESC	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.1944
p.R1891Q	DO223732	CESC	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.1944
p.R1891Q	DO230344	COCA	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.1944
p.G1908E	TCGA-90-A4ED	LUSC	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.2222
p.G1908E	DO45482	LUSC	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.2222
p.G1908R	TCGA-90-A4ED	LUSC	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.2222
p.G1908R	DO45482	LUSC	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.2222
p.G1908R	ACH-000985	Colon/Colorectal Cancer	CCLE	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.2222
p.S1898I	TCGA-AX-A2HD	UCEC	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation altering degron motif	0.623
p.S1898I	DO42608	UCEC	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation altering degron motif	0.623
p.P1886S	TCGA-D9-A3Z1	SKCM	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.0556
p.P1886S	DO38105	SKCM	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.0556
p.L1900M	TCGA-F4-6703	COAD	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation altering degron motif	0.711
p.L1900M	DO9908	COAD	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation altering degron motif	0.711
p.R1906C	TCGA-FI-A2D0	UCEC	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.2778
p.R1906C	TCGA-HC-7211	PRAD	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.2778
p.R1906C	DO36287	PRAD	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.2778
p.R1906C	DO43891	UCEC	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.2778
p.R1902C	TCGA-XK-AAIW	PRAD	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation altering degron motif	0.719
p.R1902C	DO51407	PRAD	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation altering degron motif	0.719
p.Q1914K	DO224744	COCA	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.0556
p.A1890T	DO233921	GACA	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.1667
p.L1892P	DO23330	LINC	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.2222
p.R1906H	SIDM00683	Prostate Carcinoma	GDSC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.2778
p.R1906H	LNCaP-Clone-FGC	prostate	COSMIC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.2778
p.A1907S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.25
p.A1907S	ACH-000929	Lung Cancer	CCLE	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.25
p.A1907S	NCI-H2110	lung	COSMIC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.25
p.A1889V	ACH-000935	Colon/Colorectal Cancer	CCLE	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.1389
p.A1889V	MDST8	large intestine	COSMIC	ERSILSRLT	DEG_APCC_DBOX_1	1896:1904	Mutation rewiring degron network	0.1389

Kaplan plot for CHD5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHD5

UniProt ID: Q8TDI0

Entrez ID: 26038

Protein name: Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHD5 in