DegronMD

Uniprot ID: Q8TDI0

Source protein: Chromodomain-helicase-DNA-binding protein 5

Source gene: CHD5

Class: DEG_APCC_DBOX_1

Location: 1896:1904

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5305

ASA_SCORE: 54.3222

COIL: 0.2154

CONS_SCORE: 0.3122

DSS_SCORE: 0.465

HELIX: 0.7707

FCONS_SCORE: 1.0688

RIG_SCORE: 0.7619

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1891Q	TCGA-2W-A8YY	CESC	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	0.1944
p.R1891Q	DO223732	CESC	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	0.1944
p.R1891Q	DO230344	COCA	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	0.1944
p.G1908E	TCGA-90-A4ED	LUSC	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	0.2222
p.G1908E	DO45482	LUSC	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	0.2222
p.G1908R	TCGA-90-A4ED	LUSC	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	0.2222
p.G1908R	DO45482	LUSC	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	0.2222
p.G1908R	ACH-000985	Colon/Colorectal Cancer	CCLE	ERSILSRLT	DEG_APCC_DBOX_1	0.2222
p.S1898I	TCGA-AX-A2HD	UCEC	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	0.623
p.S1898I	DO42608	UCEC	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	0.623
p.P1886S	TCGA-D9-A3Z1	SKCM	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	0.0556
p.P1886S	DO38105	SKCM	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	0.0556
p.L1900M	TCGA-F4-6703	COAD	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	0.711
p.L1900M	DO9908	COAD	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	0.711
p.R1906C	TCGA-FI-A2D0	UCEC	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	0.2778
p.R1906C	TCGA-HC-7211	PRAD	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	0.2778
p.R1906C	DO36287	PRAD	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	0.2778
p.R1906C	DO43891	UCEC	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	0.2778
p.R1902C	TCGA-XK-AAIW	PRAD	TCGA	ERSILSRLT	DEG_APCC_DBOX_1	0.719
p.R1902C	DO51407	PRAD	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	0.719
p.Q1914K	DO224744	COCA	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	0.0556
p.A1890T	DO233921	GACA	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	0.1667
p.L1892P	DO23330	LINC	ICGC	ERSILSRLT	DEG_APCC_DBOX_1	0.2222
p.R1906H	SIDM00683	Prostate Carcinoma	GDSC	ERSILSRLT	DEG_APCC_DBOX_1	0.2778
p.R1906H	LNCaP-Clone-FGC	prostate	COSMIC	ERSILSRLT	DEG_APCC_DBOX_1	0.2778
p.A1907S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	ERSILSRLT	DEG_APCC_DBOX_1	0.25
p.A1907S	ACH-000929	Lung Cancer	CCLE	ERSILSRLT	DEG_APCC_DBOX_1	0.25
p.A1907S	NCI-H2110	lung	COSMIC	ERSILSRLT	DEG_APCC_DBOX_1	0.25
p.A1889V	ACH-000935	Colon/Colorectal Cancer	CCLE	ERSILSRLT	DEG_APCC_DBOX_1	0.1389
p.A1889V	MDST8	large_intestine	COSMIC	ERSILSRLT	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERSILSRLT

Degron related mutations and impact score

Drug responses associated with CHD5 mutations

All proteins holding degron of ERSILSRLT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDI0	Chromodomain-helicase-DNA-binding protein 5	DEG_APCC_DBOX_1	1896:1904	ERSILSRLT	APC,CDC20,FZR1	0.5305	More...