DegronMD - Q8TDN4(CABLES1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R283Q	TCGA-39-5030	LUSC	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.1944
p.R283W	TCGA-A6-5665	COAD	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.1944
p.S290F	TCGA-AT-A5NU	KIRP	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	288:296	Mutation altering degron motif	0.7982
p.R284C	TCGA-AX-A06F	UCEC	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.2222
p.P303T	TCGA-BF-A1PU	SKCM	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.1389
p.A302T	TCGA-CK-4951	COAD	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.1667
p.L295M	TCGA-DA-A1I1	SKCM	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	288:296	Mutation altering degron motif	0.5999
p.R305W	TCGA-EJ-7782	PRAD	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.0833
p.R305Q	SIDM00898	Breast Carcinoma	GDSC	QRSSLETLE	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.0833
p.R305Q	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRSSLETLE	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.0833
p.R289K	SIDM00628	Breast Carcinoma	GDSC	QRSSLETLE	DEG_APCC_DBOX_1	288:296	Mutation altering degron motif	0.7237
p.K282N	SJRH30	soft tissue	COSMIC	QRSSLETLE	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.1667
p.A284T	TK10	kidney	COSMIC	QRSSLETLE	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.2222
p.A305S	RERF-LC-FM	lung	COSMIC	QRSSLETLE	DEG_APCC_DBOX_1	288:296	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons