DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
QRSSLETLE
Uniprot ID:
Q8TDN4
Source protein:
CDK5 and ABL1 enzyme substrate 1
Source gene:
CABLES1
Class:
DEG_APCC_DBOX_1
Location:
288:296
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6202
ASA_SCORE:
86.3667
COIL:
0.614
CONS_SCORE:
0.3332
DSS_SCORE:
0.4227
HELIX:
0.3232
FCONS_SCORE:
0.9581
RIG_SCORE:
0.7086
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R283Q
TCGA-39-5030
LUSC
TCGA
QRSSLETLE
DEG_APCC_DBOX_1
0.1944
p.R283W
TCGA-A6-5665
COAD
TCGA
QRSSLETLE
DEG_APCC_DBOX_1
0.1944
p.S290F
TCGA-AT-A5NU
KIRP
TCGA
QRSSLETLE
DEG_APCC_DBOX_1
0.7982
p.R284C
TCGA-AX-A06F
UCEC
TCGA
QRSSLETLE
DEG_APCC_DBOX_1
0.2222
p.P303T
TCGA-BF-A1PU
SKCM
TCGA
QRSSLETLE
DEG_APCC_DBOX_1
0.1389
p.A302T
TCGA-CK-4951
COAD
TCGA
QRSSLETLE
DEG_APCC_DBOX_1
0.1667
p.L295M
TCGA-DA-A1I1
SKCM
TCGA
QRSSLETLE
DEG_APCC_DBOX_1
0.5999
p.R305W
TCGA-EJ-7782
PRAD
TCGA
QRSSLETLE
DEG_APCC_DBOX_1
0.0833
p.R305Q
SIDM00898
Breast Carcinoma
GDSC
QRSSLETLE
DEG_APCC_DBOX_1
0.0833
p.R305Q
SIDM00404
B-Cell Non-Hodgkin's Lymphoma
GDSC
QRSSLETLE
DEG_APCC_DBOX_1
0.0833
p.R289K
SIDM00628
Breast Carcinoma
GDSC
QRSSLETLE
DEG_APCC_DBOX_1
0.7237
p.K282N
SJRH30
soft_tissue
COSMIC
QRSSLETLE
DEG_APCC_DBOX_1
0.1667
p.A284T
TK10
kidney
COSMIC
QRSSLETLE
DEG_APCC_DBOX_1
0.2222
p.A305S
RERF-LC-FM
lung
COSMIC
QRSSLETLE
DEG_APCC_DBOX_1
0.0833
Drug responses associated with CABLES1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QRSSLETLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8TDN4
CDK5 and ABL1 enzyme substrate 1
DEG_APCC_DBOX_1
288:296
QRSSLETLE
APC,CDC20,FZR1
0.6202
More...