DegronMD

Uniprot ID: Q8TDN4

Source protein: CDK5 and ABL1 enzyme substrate 1

Source gene: CABLES1

Class: DEG_APCC_DBOX_1

Location: 288:296

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6202

ASA_SCORE: 86.3667

COIL: 0.614

CONS_SCORE: 0.3332

DSS_SCORE: 0.4227

HELIX: 0.3232

FCONS_SCORE: 0.9581

RIG_SCORE: 0.7086

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S290F	TCGA-AT-A5NU	KIRP	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	0.7982
p.R289K	SIDM00628	Breast Carcinoma	GDSC	QRSSLETLE	DEG_APCC_DBOX_1	0.7237
p.L295M	TCGA-DA-A1I1	SKCM	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	0.5999
p.R284C	TCGA-AX-A06F	UCEC	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	0.2222
p.A284T	TK10	kidney	COSMIC	QRSSLETLE	DEG_APCC_DBOX_1	0.2222
p.R283Q	TCGA-39-5030	LUSC	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	0.1944
p.R283W	TCGA-A6-5665	COAD	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	0.1944
p.A302T	TCGA-CK-4951	COAD	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	0.1667
p.K282N	SJRH30	soft_tissue	COSMIC	QRSSLETLE	DEG_APCC_DBOX_1	0.1667
p.P303T	TCGA-BF-A1PU	SKCM	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	0.1389
p.R305W	TCGA-EJ-7782	PRAD	TCGA	QRSSLETLE	DEG_APCC_DBOX_1	0.0833
p.R305Q	SIDM00898	Breast Carcinoma	GDSC	QRSSLETLE	DEG_APCC_DBOX_1	0.0833
p.R305Q	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRSSLETLE	DEG_APCC_DBOX_1	0.0833
p.A305S	RERF-LC-FM	lung	COSMIC	QRSSLETLE	DEG_APCC_DBOX_1	0.0833

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDN4	CDK5 and ABL1 enzyme substrate 1	DEG_APCC_DBOX_1	288:296	QRSSLETLE	APC,CDC20,FZR1	0.6202	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons