DegronMD - Q8TDN6(BRIX1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I318T	TCGA-A5-A0G2	UCEC	TCGA	VFVTPAEE	DEG_SCF_FBW7_2	306:313	Mutation rewiring degron network	0.1944
p.I318T	TCGA-CD-8536	STAD	TCGA	VFVTPAEE	DEG_SCF_FBW7_2	306:313	Mutation rewiring degron network	0.1944
p.I318T	DO47827	STAD	ICGC	VFVTPAEE	DEG_SCF_FBW7_2	306:313	Mutation rewiring degron network	0.1944
p.I318T	DO41235	UCEC	ICGC	VFVTPAEE	DEG_SCF_FBW7_2	306:313	Mutation rewiring degron network	0.1944
p.A304T	TCGA-AP-A051	UCEC	TCGA	VFVTPAEE	DEG_SCF_FBW7_2	306:313	Mutation rewiring degron network	0.2778
p.A304T	DO42673	UCEC	ICGC	VFVTPAEE	DEG_SCF_FBW7_2	306:313	Mutation rewiring degron network	0.2778
p.A311V	TCGA-AX-A2HD	UCEC	TCGA	VFVTPAEE	DEG_SCF_FBW7_2	306:313	Mutation altering degron motif	0.5825
p.A311V	DO42608	UCEC	ICGC	VFVTPAEE	DEG_SCF_FBW7_2	306:313	Mutation altering degron motif	0.5825
p.V306L	TCGA-WE-A8ZY	SKCM	TCGA	VFVTPAEE	DEG_SCF_FBW7_2	306:313	Mutation altering degron motif	0.5654
p.V306L	DO51292	SKCM	ICGC	VFVTPAEE	DEG_SCF_FBW7_2	306:313	Mutation altering degron motif	0.5654
p.V321I	DO38404	STAD	ICGC	VFVTPAEE	DEG_SCF_FBW7_2	306:313	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons