DegronMD

Uniprot ID: Q8TDN6

Source protein: Ribosome biogenesis protein BRX1 homolog

Source gene: BRIX1

Class: DEG_SCF_FBW7_2

Location: 306:313

E3 ligase: FBXW7

DEGRON score: 0.9944

ASA_SCORE: 71.1375

COIL: 0.7045

CONS_SCORE: 0.4994

DSS_SCORE: 0.4231

HELIX: 0.2376

FCONS_SCORE: 1.0702

RIG_SCORE: 0.7693

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I318T	TCGA-A5-A0G2	UCEC	TCGA	VFVTPAEE	DEG_SCF_FBW7_2	0.1944
p.I318T	TCGA-CD-8536	STAD	TCGA	VFVTPAEE	DEG_SCF_FBW7_2	0.1944
p.I318T	DO47827	STAD	ICGC	VFVTPAEE	DEG_SCF_FBW7_2	0.1944
p.I318T	DO41235	UCEC	ICGC	VFVTPAEE	DEG_SCF_FBW7_2	0.1944
p.A304T	TCGA-AP-A051	UCEC	TCGA	VFVTPAEE	DEG_SCF_FBW7_2	0.2778
p.A304T	DO42673	UCEC	ICGC	VFVTPAEE	DEG_SCF_FBW7_2	0.2778
p.A311V	TCGA-AX-A2HD	UCEC	TCGA	VFVTPAEE	DEG_SCF_FBW7_2	0.5825
p.A311V	DO42608	UCEC	ICGC	VFVTPAEE	DEG_SCF_FBW7_2	0.5825
p.V306L	TCGA-WE-A8ZY	SKCM	TCGA	VFVTPAEE	DEG_SCF_FBW7_2	0.5654
p.V306L	DO51292	SKCM	ICGC	VFVTPAEE	DEG_SCF_FBW7_2	0.5654
p.V321I	DO38404	STAD	ICGC	VFVTPAEE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDN6	Ribosome biogenesis protein BRX1 homolog	DEG_SCF_FBW7_2	306:313	VFVTPAEE	FBXW7	0.9944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons