DegronMD - Q8TDT2(GPR152)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P460L	TCGA-DF-A2KZ	UCEC	TCGA	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation rewiring degron network	0.0833
p.P460L	DO52409	UCEC	ICGC	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation rewiring degron network	0.0833
p.P460L	SIDM00509	Small Cell Lung Carcinoma	GDSC	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation rewiring degron network	0.0833
p.P460L	ACH-000187	Lung Cancer	CCLE	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation rewiring degron network	0.0833
p.A450T	TCGA-FP-8211	STAD	TCGA	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation altering degron motif	0.6028
p.A450T	DO47847	STAD	ICGC	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation altering degron motif	0.6028
p.P439T	TCGA-L9-A7SV	LUAD	TCGA	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation rewiring degron network	0.1667
p.P439T	DO49875	LUAD	ICGC	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation rewiring degron network	0.1667
p.A450D	DO228948	LICA	ICGC	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation altering degron motif	0.6682
p.P456T	DO229027	LICA	ICGC	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation rewiring degron network	0.1944
p.P456T	DO229035	LICA	ICGC	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation rewiring degron network	0.1944
p.S458R	DO229037	LICA	ICGC	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation rewiring degron network	0.1389
p.T459I	DO23416	LINC	ICGC	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation rewiring degron network	0.1111
p.P437S	DO218855	SKCA	ICGC	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation rewiring degron network	0.1111
p.P449S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation altering degron motif	0.5641
p.P449S	ACH-002256	Leukemia	CCLE	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation altering degron motif	0.5641
p.P449S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PATPPAS	DEG_SCF_FBW7_1	445:451	Mutation altering degron motif	0.5641

Kaplan plot for GPR152 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPR152

UniProt ID: Q8TDT2

Entrez ID: 390212

Protein name: Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPR152 in