DegronMD

Uniprot ID: Q8TDT2

Source protein: Probable G-protein coupled receptor 152

Source gene: GPR152

Class: DEG_SCF_FBW7_1

Location: 445:451

E3 ligase: FBXW7

DEGRON score: 0.9796

ASA_SCORE: 68.5

COIL: 0.9571

CONS_SCORE: 0.2954

DSS_SCORE: 0.8927

HELIX: 0.0239

FCONS_SCORE: 0.903

RIG_SCORE: 0.51

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P460L	TCGA-DF-A2KZ	UCEC	TCGA	PATPPAS	DEG_SCF_FBW7_1	0.0833
p.P460L	DO52409	UCEC	ICGC	PATPPAS	DEG_SCF_FBW7_1	0.0833
p.P460L	SIDM00509	Small Cell Lung Carcinoma	GDSC	PATPPAS	DEG_SCF_FBW7_1	0.0833
p.P460L	ACH-000187	Lung Cancer	CCLE	PATPPAS	DEG_SCF_FBW7_1	0.0833
p.A450T	TCGA-FP-8211	STAD	TCGA	PATPPAS	DEG_SCF_FBW7_1	0.6028
p.A450T	DO47847	STAD	ICGC	PATPPAS	DEG_SCF_FBW7_1	0.6028
p.P439T	TCGA-L9-A7SV	LUAD	TCGA	PATPPAS	DEG_SCF_FBW7_1	0.1667
p.P439T	DO49875	LUAD	ICGC	PATPPAS	DEG_SCF_FBW7_1	0.1667
p.A450D	DO228948	LICA	ICGC	PATPPAS	DEG_SCF_FBW7_1	0.6682
p.P456T	DO229027	LICA	ICGC	PATPPAS	DEG_SCF_FBW7_1	0.1944
p.P456T	DO229035	LICA	ICGC	PATPPAS	DEG_SCF_FBW7_1	0.1944
p.S458R	DO229037	LICA	ICGC	PATPPAS	DEG_SCF_FBW7_1	0.1389
p.T459I	DO23416	LINC	ICGC	PATPPAS	DEG_SCF_FBW7_1	0.1111
p.P437S	DO218855	SKCA	ICGC	PATPPAS	DEG_SCF_FBW7_1	0.1111
p.P449S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PATPPAS	DEG_SCF_FBW7_1	0.5641
p.P449S	ACH-002256	Leukemia	CCLE	PATPPAS	DEG_SCF_FBW7_1	0.5641
p.P449S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PATPPAS	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDT2	Probable G-protein coupled receptor 152	DEG_SCF_FBW7_1	445:451	PATPPAS	FBXW7	0.9796	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons