DegronMD - Q8TDW7(FAT3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T3249I	TCGA-D1-A17A	UCEC	TCGA	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.25
p.P3246S	TCGA-DD-A113	LIHC	TCGA	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation altering degron motif	0.5641
p.P3246S	DO22920	LIHC	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation altering degron motif	0.5641
p.P3234L	TCGA-EE-A3JB	SKCM	TCGA	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.2222
p.P3234L	DO51250	SKCM	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.2222
p.R3256L	DO1078	BRCA	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.0556
p.R3256L	DO26530	LUSC	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.0556
p.R3256L	DO26602	LUSC	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.0556
p.R3235W	DO222798	COCA	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.25
p.R3235W	DO220906	MELA	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.25
p.R3235W	ACH-001841	Bile Duct Cancer	CCLE	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.25
p.K3252N	DO234213	ESAD	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.1667
p.P3251S	DO218769	GACA	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.1944
p.P3243L	DO220873	MELA	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation altering degron motif	0.7582
p.PP3233PS	DO222363	MELA	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0
p.P3251R	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.1944
p.P3251R	NCI-H650	lung	COSMIC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.1944
p.R3238K	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation altering degron motif	0.6126
p.R3238K	KYSE-150	oesophagus	COSMIC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation altering degron motif	0.6126
p.R3235L	ACH-000334	Lymphoma	CCLE	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.25
p.R3235L	DB	haematopoietic and lymphoid tissue	COSMIC	RRDYLVTVP	DEG_APCC_DBOX_1	3238:3246	Mutation rewiring degron network	0.25

Kaplan plot for FAT3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAT3

UniProt ID: Q8TDW7

Entrez ID: 120114

Protein name: Protocadherin Fat 3 (hFat3) (Cadherin family member 15) (FAT tumor suppressor homolog 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAT3 in