DegronMD

Uniprot ID: Q8TDW7

Source protein: Protocadherin Fat 3

Source gene: FAT3

Class: DEG_APCC_DBOX_1

Location: 3238:3246

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7937

ASA_SCORE: 60.5778

COIL: 0.2233

CONS_SCORE: 0.5149

DSS_SCORE: 0.4606

HELIX: 0.0071

FCONS_SCORE: 0.7988

RIG_SCORE: 0.8576

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3249I	TCGA-D1-A17A	UCEC	TCGA	RRDYLVTVP	DEG_APCC_DBOX_1	0.25
p.P3246S	TCGA-DD-A113	LIHC	TCGA	RRDYLVTVP	DEG_APCC_DBOX_1	0.5641
p.P3246S	DO22920	LIHC	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	0.5641
p.P3234L	TCGA-EE-A3JB	SKCM	TCGA	RRDYLVTVP	DEG_APCC_DBOX_1	0.2222
p.P3234L	DO51250	SKCM	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	0.2222
p.R3256L	DO1078	BRCA	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	0.0556
p.R3256L	DO26530	LUSC	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	0.0556
p.R3256L	DO26602	LUSC	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	0.0556
p.R3235W	DO222798	COCA	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	0.25
p.R3235W	DO220906	MELA	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	0.25
p.R3235W	ACH-001841	Bile Duct Cancer	CCLE	RRDYLVTVP	DEG_APCC_DBOX_1	0.25
p.K3252N	DO234213	ESAD	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	0.1667
p.P3251S	DO218769	GACA	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	0.1944
p.P3243L	DO220873	MELA	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	0.7582
p.PP3233PS	DO222363	MELA	ICGC	RRDYLVTVP	DEG_APCC_DBOX_1	0
p.P3251R	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	RRDYLVTVP	DEG_APCC_DBOX_1	0.1944
p.P3251R	NCI-H650	lung	COSMIC	RRDYLVTVP	DEG_APCC_DBOX_1	0.1944
p.R3238K	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	RRDYLVTVP	DEG_APCC_DBOX_1	0.6126
p.R3238K	KYSE-150	oesophagus	COSMIC	RRDYLVTVP	DEG_APCC_DBOX_1	0.6126
p.R3235L	ACH-000334	Lymphoma	CCLE	RRDYLVTVP	DEG_APCC_DBOX_1	0.25
p.R3235L	DB	haematopoietic_and_lymphoid_tissue	COSMIC	RRDYLVTVP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDW7	Protocadherin Fat 3	DEG_APCC_DBOX_1	3238:3246	RRDYLVTVP	APC,CDC20,FZR1	0.7937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons