DegronMD - Q8TDY2(RB1CC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I1025L	TCGA-AP-A0LM	UCEC	TCGA	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.1389
p.I1025L	DO43306	UCEC	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.1389
p.K1019Q	TCGA-B5-A11E	UCEC	TCGA	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.3056
p.K1019Q	DO41644	UCEC	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.3056
p.D1009Y	TCGA-CV-A45Z	HNSC	TCGA	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.3056
p.D1009Y	DO52064	HNSC	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.3056
p.N1021T	TCGA-VQ-A91D	STAD	TCGA	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.25
p.N1021T	DO51783	STAD	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.25
p.S1013T	DO224852	BRCA	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.6005
p.S1013T	DO52550	BRCA	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.6005
p.I1028V	DO223428	CLLE	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.0556
p.N1021S	DO229213	THCA	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.25
p.V1012A	SIDM01015	Chronic Myelogenous Leukemia	GDSC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.5825
p.V1012A	ACH-000326	Leukemia	CCLE	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.5825
p.V1012A	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.5825
p.R1011G	SIDM00799	Glioblastoma	GDSC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.7568
p.R1011G	ACH-000558	Brain Cancer	CCLE	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.7568
p.R1011G	A172	central nervous system	COSMIC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.7568
p.D1009G	SIDM00537	Colorectal Carcinoma	GDSC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.3056
p.D1009G	ACH-000982	Colon/Colorectal Cancer	CCLE	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.3056
p.D1009G	ACH-001345	Colon/Colorectal Cancer	CCLE	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.3056
p.D1009G	GP5d	large intestine	COSMIC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.3056
p.S1013Y	SIDM00118	Colorectal Carcinoma	GDSC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.6009
p.S1013Y	ACH-001081	Colon/Colorectal Cancer	CCLE	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.6009
p.S1013Y	HCC2998	large intestine	COSMIC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation altering degron motif	0.6009
p.I1000M	SIDM01679	Small Cell Lung Carcinoma	GDSC	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.0556
p.I1000M	ACH-000523	Lung Cancer	CCLE	HRVSLEELK	DEG_APCC_DBOX_1	1010:1018	Mutation rewiring degron network	0.0556

Kaplan plot for RB1CC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RB1CC1

UniProt ID: Q8TDY2

Entrez ID: 9821

Protein name: RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RB1CC1 in