DegronMD

Uniprot ID: Q8TDY2

Source protein: RB1-inducible coiled-coil protein 1

Source gene: RB1CC1

Class: DEG_APCC_DBOX_1

Location: 1010:1018

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5173

ASA_SCORE: 102.1778

COIL: 0.0704

CONS_SCORE: 0.4086

DSS_SCORE: 0.3713

HELIX: 0.9277

FCONS_SCORE: 1.0871

RIG_SCORE: 0.7993

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1025L	TCGA-AP-A0LM	UCEC	TCGA	HRVSLEELK	DEG_APCC_DBOX_1	0.1389
p.I1025L	DO43306	UCEC	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	0.1389
p.K1019Q	TCGA-B5-A11E	UCEC	TCGA	HRVSLEELK	DEG_APCC_DBOX_1	0.3056
p.K1019Q	DO41644	UCEC	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	0.3056
p.D1009Y	TCGA-CV-A45Z	HNSC	TCGA	HRVSLEELK	DEG_APCC_DBOX_1	0.3056
p.D1009Y	DO52064	HNSC	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	0.3056
p.N1021T	TCGA-VQ-A91D	STAD	TCGA	HRVSLEELK	DEG_APCC_DBOX_1	0.25
p.N1021T	DO51783	STAD	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	0.25
p.S1013T	DO224852	BRCA	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	0.6005
p.S1013T	DO52550	BRCA	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	0.6005
p.I1028V	DO223428	CLLE	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	0.0556
p.N1021S	DO229213	THCA	ICGC	HRVSLEELK	DEG_APCC_DBOX_1	0.25
p.V1012A	SIDM01015	Chronic Myelogenous Leukemia	GDSC	HRVSLEELK	DEG_APCC_DBOX_1	0.5825
p.V1012A	ACH-000326	Leukemia	CCLE	HRVSLEELK	DEG_APCC_DBOX_1	0.5825
p.V1012A	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	HRVSLEELK	DEG_APCC_DBOX_1	0.5825
p.R1011G	SIDM00799	Glioblastoma	GDSC	HRVSLEELK	DEG_APCC_DBOX_1	0.7568
p.R1011G	ACH-000558	Brain Cancer	CCLE	HRVSLEELK	DEG_APCC_DBOX_1	0.7568
p.R1011G	A172	central_nervous_system	COSMIC	HRVSLEELK	DEG_APCC_DBOX_1	0.7568
p.D1009G	SIDM00537	Colorectal Carcinoma	GDSC	HRVSLEELK	DEG_APCC_DBOX_1	0.3056
p.D1009G	ACH-000982	Colon/Colorectal Cancer	CCLE	HRVSLEELK	DEG_APCC_DBOX_1	0.3056
p.D1009G	ACH-001345	Colon/Colorectal Cancer	CCLE	HRVSLEELK	DEG_APCC_DBOX_1	0.3056
p.D1009G	GP5d	large_intestine	COSMIC	HRVSLEELK	DEG_APCC_DBOX_1	0.3056
p.S1013Y	SIDM00118	Colorectal Carcinoma	GDSC	HRVSLEELK	DEG_APCC_DBOX_1	0.6009
p.S1013Y	ACH-001081	Colon/Colorectal Cancer	CCLE	HRVSLEELK	DEG_APCC_DBOX_1	0.6009
p.S1013Y	HCC2998	large_intestine	COSMIC	HRVSLEELK	DEG_APCC_DBOX_1	0.6009
p.I1000M	SIDM01679	Small Cell Lung Carcinoma	GDSC	HRVSLEELK	DEG_APCC_DBOX_1	0.0556
p.I1000M	ACH-000523	Lung Cancer	CCLE	HRVSLEELK	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: HRVSLEELK

Degron related mutations and impact score

Drug responses associated with RB1CC1 mutations

All proteins holding degron of HRVSLEELK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDY2	RB1-inducible coiled-coil protein 1	DEG_APCC_DBOX_1	1010:1018	HRVSLEELK	APC,CDC20,FZR1	0.5173	More...