DegronMD - Q8TE04(PANK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R130C	TCGA-2G-AAFE	TGCT	TCGA	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.25
p.R130C	DO230326	COCA	ICGC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.25
p.N118D	DO234362	ESAD	ICGC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.2778
p.E128K	DO228261	LICA	ICGC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.3056
p.E128K	DO42472	UCEC	ICGC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.3056
p.N130K	DO228948	LICA	ICGC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.25
p.T136N	DO229026	LICA	ICGC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0833
p.H135Q	DO229009	LICA	ICGC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.1111
p.S116I	DO49657	LIHC	ICGC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.2222
p.R127P	DO229085	THCA	ICGC	LQRGRLSR	SCF_FBXL2	120:127	Mutation altering degron motif	0.6401
p.P115L	DO42480	UCEC	ICGC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.1944
p.G111R	SIDM00454	Rhabdomyosarcoma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0833
p.G111R	SIDM00087	Plasma Cell Myeloma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0833
p.G111R	SIDM00633	Breast Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0833
p.G111R	SIDM00654	Small Cell Lung Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0833
p.G111R	SIDM01112	Osteosarcoma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0833
p.G111R	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0833
p.G111R	SIDM00309	Mesothelioma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0833
p.G111R	SIDM00032	Bladder Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0833
p.G111R	SIDM00720	Mesothelioma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0833
p.G111R	SIDM00760	Small Cell Lung Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0833
p.G111R	SIDM01686	Chronic Myelogenous Leukemia	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0833
p.G111R	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0833
p.A135V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.1111
p.E112K	SIDM00417	Plasma Cell Myeloma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.1111
p.E112K	U-266	haematopoietic and lymphoid tissue	COSMIC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.1111
p.G137D	SIDM00854	Burkitt's Lymphoma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0556
p.G137D	ACH-000162	Lymphoma	CCLE	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0556
p.P133L	SIDM00381	Cervical Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.1667
p.P133L	SIDM00500	Colorectal Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.1667
p.L120P	ACH-000895	Colon/Colorectal Cancer	CCLE	LQRGRLSR	SCF_FBXL2	120:127	Mutation altering degron motif	0.7582
p.L120P	CL-34	large intestine	COSMIC	LQRGRLSR	SCF_FBXL2	120:127	Mutation altering degron motif	0.7582

Kaplan plot for PANK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PANK1

UniProt ID: Q8TE04

Entrez ID: 53354

Protein name: Pantothenate kinase 1 (hPanK) (hPanK1) (EC 2.7.1.33) (Pantothenic acid kinase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PANK1 in