DegronMD

Uniprot ID: Q8TE04

Source protein: Pantothenate kinase 1

Source gene: PANK1

Class: SCF_FBXL2

Location: 120:127

E3 ligase: FBXL2

DEGRON score: 0.8064

ASA_SCORE: 95.7875

COIL: 0.7169

CONS_SCORE: 0.4348

DSS_SCORE: 0.8282

HELIX: 0.2565

FCONS_SCORE: 1.1

RIG_SCORE: 0.6239

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R130C	TCGA-2G-AAFE	TGCT	TCGA	LQRGRLSR	SCF_FBXL2	0.25
p.R130C	DO230326	COCA	ICGC	LQRGRLSR	SCF_FBXL2	0.25
p.N118D	DO234362	ESAD	ICGC	LQRGRLSR	SCF_FBXL2	0.2778
p.E128K	DO228261	LICA	ICGC	LQRGRLSR	SCF_FBXL2	0.3056
p.E128K	DO42472	UCEC	ICGC	LQRGRLSR	SCF_FBXL2	0.3056
p.N130K	DO228948	LICA	ICGC	LQRGRLSR	SCF_FBXL2	0.25
p.T136N	DO229026	LICA	ICGC	LQRGRLSR	SCF_FBXL2	0.0833
p.H135Q	DO229009	LICA	ICGC	LQRGRLSR	SCF_FBXL2	0.1111
p.S116I	DO49657	LIHC	ICGC	LQRGRLSR	SCF_FBXL2	0.2222
p.R127P	DO229085	THCA	ICGC	LQRGRLSR	SCF_FBXL2	0.6401
p.P115L	DO42480	UCEC	ICGC	LQRGRLSR	SCF_FBXL2	0.1944
p.G111R	SIDM00454	Rhabdomyosarcoma	GDSC	LQRGRLSR	SCF_FBXL2	0.0833
p.G111R	SIDM00087	Plasma Cell Myeloma	GDSC	LQRGRLSR	SCF_FBXL2	0.0833
p.G111R	SIDM00633	Breast Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	0.0833
p.G111R	SIDM00654	Small Cell Lung Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	0.0833
p.G111R	SIDM01112	Osteosarcoma	GDSC	LQRGRLSR	SCF_FBXL2	0.0833
p.G111R	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	0.0833
p.G111R	SIDM00309	Mesothelioma	GDSC	LQRGRLSR	SCF_FBXL2	0.0833
p.G111R	SIDM00032	Bladder Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	0.0833
p.G111R	SIDM00720	Mesothelioma	GDSC	LQRGRLSR	SCF_FBXL2	0.0833
p.G111R	SIDM00760	Small Cell Lung Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	0.0833
p.G111R	SIDM01686	Chronic Myelogenous Leukemia	GDSC	LQRGRLSR	SCF_FBXL2	0.0833
p.G111R	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	0.0833
p.A135V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LQRGRLSR	SCF_FBXL2	0.1111
p.E112K	SIDM00417	Plasma Cell Myeloma	GDSC	LQRGRLSR	SCF_FBXL2	0.1111
p.E112K	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	LQRGRLSR	SCF_FBXL2	0.1111
p.G137D	SIDM00854	Burkitt's Lymphoma	GDSC	LQRGRLSR	SCF_FBXL2	0.0556
p.G137D	ACH-000162	Lymphoma	CCLE	LQRGRLSR	SCF_FBXL2	0.0556
p.P133L	SIDM00381	Cervical Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	0.1667
p.P133L	SIDM00500	Colorectal Carcinoma	GDSC	LQRGRLSR	SCF_FBXL2	0.1667
p.L120P	ACH-000895	Colon/Colorectal Cancer	CCLE	LQRGRLSR	SCF_FBXL2	0.7582
p.L120P	CL-34	large_intestine	COSMIC	LQRGRLSR	SCF_FBXL2	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQRGRLSR

Degron related mutations and impact score

Drug responses associated with PANK1 mutations

All proteins holding degron of LQRGRLSR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TE04	Pantothenate kinase 1	SCF_FBXL2	120:127	LQRGRLSR	FBXL2	0.8064	More...