DegronMD - Q8TE56(ADAMTS17)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E193K	TCGA-34-2596	LUSC	TCGA	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.2778
p.E193K	DO26508	LUSC	ICGC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.2778
p.H178L	TCGA-43-8118	LUSC	TCGA	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.1111
p.H178L	DO45471	LUSC	ICGC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.1111
p.C201F	TCGA-CK-4951	COAD	TCGA	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.0556
p.C201F	DO10582	COAD	ICGC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.0556
p.L200P	TCGA-DF-A2KN	UCEC	TCGA	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.0833
p.L200P	DO223282	UCEC	ICGC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.0833
p.S185F	TCGA-EE-A2GR	SKCM	TCGA	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.3056
p.S185F	DO37996	SKCM	ICGC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.3056
p.S189N	DO234462	ESAD	ICGC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation altering degron motif	0.5958
p.T187I	DO11854	GBM	ICGC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation altering degron motif	0.7078
p.R182S	DO229041	LICA	ICGC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.2222
p.R176Q	SIDM01104	Melanoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.0556
p.R176Q	SIDM01051	Ovarian Carcinoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.0556
p.R176Q	ACH-000640	Skin Cancer	CCLE	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.0556
p.R176Q	ACH-000936	Ovarian Cancer	CCLE	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.0556
p.R176Q	EFO-27	ovary	COSMIC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.0556
p.R176Q	SK-MEL-31	skin	COSMIC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.0556
p.K183R	SIDM00662	Melanoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation substituting flanking lysine	0.3611
p.K183R	SIDM00845	Burkitt's Lymphoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation substituting flanking lysine	0.3611
p.K183R	SIDM01071	Small Cell Lung Carcinoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation substituting flanking lysine	0.3611
p.K183R	SIDM00121	T-Lymphoblastic Leukemia	GDSC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation substituting flanking lysine	0.3611
p.K183R	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation substituting flanking lysine	0.3611
p.K183R	SIDM01763	Rhabdomyosarcoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation substituting flanking lysine	0.3611
p.T187N	SIDM00504	Glioma	GDSC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation altering degron motif	0.7055
p.T187N	ACH-001126	Brain Cancer	CCLE	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation altering degron motif	0.7055
p.T187N	MOG-G-UVW	central nervous system	COSMIC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation altering degron motif	0.7055
p.R181K	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	LTPSPS	DEG_SCF_FBW7_1	186:191	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAMTS17

UniProt ID: Q8TE56

Entrez ID: 170691

Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAM-TS 17) (ADAM-TS17) (ADAMTS-17) (EC 3.4.24.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAMTS17 in